用于高效磁共振/光声双模态成像引导光热治疗的锰（II）螯合功能化硫化铜纳米颗粒

Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.

作者信息

Liu Renfa, Jing Lijia, Peng Dong, Li Yong, Tian Jie, Dai Zhifei

机构信息

1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;

1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China; ; 3. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.

出版信息

Theranostics. 2015 Jul 25;5(10):1144-53. doi: 10.7150/thno.11754. eCollection 2015.

DOI:10.7150/thno.11754

PMID:26284144

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4533097/

Abstract

The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.

摘要

将诊断和治疗功能整合到一个纳米平台在癌症治疗中显示出巨大的潜力。在本研究中，采用简便的水热法成功制备了锰（II）螯合物功能化的硫化铜纳米颗粒。所获得的超小纳米颗粒表现出优异的光热效应和光声活性。此外，高负载量的Mn（II）螯合物使纳米颗粒成为磁共振成像（MRI）中具有吸引力的T1造影剂。体内光声成像（PAI）结果表明，纳米颗粒在全身给药后24小时内可有效积聚在肿瘤部位，MRI测试进一步证实了这一点。随后在体内实现了癌症的光热治疗，且未观察到任何副作用。因此，用Mn（II）螯合物功能化的硫化铜纳米颗粒作为用于癌症的MR/PA双模态成像引导光热治疗的诊疗纳米药物具有巨大的潜力。