Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Curr Opin Struct Biol. 2018 Aug;51:1-8. doi: 10.1016/j.sbi.2017.12.005. Epub 2018 Jan 6.
Recent achievements in development of protein assembles within cells have extended biosupramolecular composites into a new era with versatile applications in the fields of biomaterial and biotechnology. Using methods with biological and physicochemical routes has made this era of research more interesting and challenging. Further advances in protein engineering have facilitated efficient fabrication of supramolecular complexes within living cells. Here, we provide a review of recent efforts to engineer protein assemblies within cells and describe the promising properties of these assemblies.
近年来，细胞内蛋白质组装的发展取得了新的突破，将生物超分子复合材料推向了一个新时代，在生物材料和生物技术领域具有广泛的应用。利用生物学和物理化学方法使得这一研究领域变得更加有趣和具有挑战性。蛋白质工程的进一步发展促进了活细胞内超分子复合物的高效构建。本文综述了近年来在细胞内工程蛋白质组装方面的努力，并描述了这些组装体的有前途的特性。
