POLYMAT and Department of Applied Chemistry, University of the Basque Country UPV/EHU, Avda. Manuel de Lardizabal 3, E-20018 Donostia - San Sebastian, Spain; IKERBASQUE, Basque Foundation for Science, Maria Diaz de Haro 3, E-48013 Bilbao, Spain.
IKERBASQUE, Basque Foundation for Science, Maria Diaz de Haro 3, E-48013 Bilbao, Spain; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón, 194, E-20014 Donostia - San Sebastian, Spain.
Curr Opin Struct Biol. 2020 Aug;63:74-81. doi: 10.1016/j.sbi.2020.04.005. Epub 2020 May 30.
This review aims to summarize the last advances on the field of protein engineering towards functional bionanomaterials. Albeit being this an emerging research field, multidisciplinary perspectives in the design of synthetic protein-based hybrid bionanomaterials have resulted in significant progresses. The review covers the definition of bionanomaterials as such and the description of the main methodological approaches currently employed for their assembly. In this context, special emphasis is placed on the fundamental role of protein design. Then, a general overview of the most recent advances related to the fabrication and application of protein-based bionanomaterials in several applications is provided, with special focus on catalysis. Finally, key aspects to be considered by the research community to establish the path for significant future developments in this promising field are discussed.
本综述旨在总结蛋白质工程在功能仿生材料领域的最新进展。尽管这是一个新兴的研究领域，但在设计基于合成蛋白质的杂交仿生材料时，多学科视角已经取得了重大进展。本综述涵盖了仿生材料的定义以及目前用于其组装的主要方法学方法的描述。在这方面，特别强调了蛋白质设计的基础作用。然后，提供了基于蛋白质的仿生材料在多个应用领域中的制造和应用的最新进展的概述，特别关注催化。最后，讨论了研究界需要考虑的关键方面，为该有前途的领域的未来重大发展奠定基础。
