Department of Neurosurgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Department of Neurosurgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Hum Pathol. 2018 Apr;74:129-134. doi: 10.1016/j.humpath.2017.12.019. Epub 2018 Jan 6.
Chordomas are rare, locally aggressive malignancies that are often difficult to eradicate. Surgery and radiotherapy are the first-line treatments, but the probability of local recurrence is high. According to our previous research, c-Cbl and Cbl-b have been linked to tumor progression and poor prognosis of glioma. However, their role in skull base chordomas is unclear. To clarify this issue, in the present study, we analyzed the expression of c-Cbl and Cbl-b in relation to the clinicopathological features and clinical outcome of skull base chordoma patients (n = 70). C-Cbl and Cbl-b expression was evaluated by immunohistochemistry, and a survival analysis was performed based on clinical data. We found that c-Cbl and Cbl-b were upregulated in 30 of 70 (42.9%) and 32 of 70 (45.7%) patients with skull base chordomas, respectively. A Kaplan-Meier analysis and log-rank test indicated that high c-Cbl and Cbl-b levels were significantly associated with overall survival (P = .003 and P = .008, respectively) and progression-free survival (P < .001 and P = .022, respectively). These data indicated that c-Cbl and Cbl-b expression in skull base chordomas can predict tumor invasion and poor prognosis and is therefore a potential therapeutic target for chordoma treatment.
软骨肉瘤是一种罕见的局部侵袭性恶性肿瘤，通常难以根除。手术和放疗是一线治疗方法，但局部复发的概率很高。根据我们之前的研究，c-Cbl 和 Cbl-b 与神经胶质瘤的肿瘤进展和不良预后有关。然而，它们在颅底软骨肉瘤中的作用尚不清楚。为了阐明这个问题，在本研究中，我们分析了 c-Cbl 和 Cbl-b 的表达与颅底软骨肉瘤患者（n = 70）的临床病理特征和临床结果的关系。通过免疫组织化学评估 c-Cbl 和 Cbl-b 的表达，并根据临床数据进行生存分析。我们发现，在 70 例颅底软骨肉瘤患者中，分别有 30 例（42.9%）和 32 例（45.7%）患者的 c-Cbl 和 Cbl-b 表达上调。Kaplan-Meier 分析和对数秩检验表明，c-Cbl 和 Cbl-b 高水平与总生存（P =.003 和 P =.008）和无进展生存（P <.001 和 P =.022）显著相关。这些数据表明，颅底软骨肉瘤中 c-Cbl 和 Cbl-b 的表达可以预测肿瘤侵袭和不良预后，因此是软骨肉瘤治疗的潜在治疗靶点。
