黄花蒿对感染棘阿米巴属的小鼠脑内Toll样受体表达的影响
Influence of Artemisia annua L. on toll-like receptor expression in brain of mice infected with Acanthamoeba sp.
作者信息
Wojtkowiak-Giera Agnieszka, Derda Monika, Kosik-Bogacka Danuta, Kolasa-Wołosiuk Agnieszka, Solarczyk Piotr, Cholewiński Marcin, Wandurska-Nowak Elżbieta, Jagodziński Paweł P, Hadaś Edward
机构信息
Department of Biology and Medical Parasitology, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland.
Department of Biology and Medical Parasitology, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland.
出版信息
Exp Parasitol. 2018 Feb;185:17-22. doi: 10.1016/j.exppara.2018.01.008. Epub 2018 Jan 6.
The treatment of acanthamoebiasis is a still a problem. Our previous studies showed that the application of extracts from Artemisia annua L. significantly prolonged the survival of mice infected by Acanthamoeba. This plant has medicinal properties in the treatment of human parasitic diseases. The aim of this study was to evaluate the effects of A. annua on expression of Toll-like receptors (TLRs) 2 and 4 in brain of mice with Acanthamoeba infection. Mice were infected with Acanthamoeba sp. strain Ac309 (KY203908) by intranasal inoculation without and after application of A. annua extract. The administration of extract from A. annua significantly reduced the level of expression of TLR2 and modified the level of expression of TLR4. A. annua extract is a natural substance that is well tolerated in animals and may be considered as a combination therapy in treatment of acanthamoebiasis. Our study suggested that A. annua extract may be used as an alternative therapeutic tool.
棘阿米巴病的治疗仍然是一个难题。我们之前的研究表明，青蒿提取物的应用显著延长了感染棘阿米巴的小鼠的存活时间。这种植物在治疗人类寄生虫病方面具有药用特性。本研究的目的是评估青蒿对棘阿米巴感染小鼠大脑中Toll样受体（TLR）2和4表达的影响。在应用青蒿提取物之前和之后，通过鼻内接种使小鼠感染棘阿米巴属菌株Ac309（KY203908）。青蒿提取物的给药显著降低了TLR2的表达水平并改变了TLR4的表达水平。青蒿提取物是一种在动物中耐受性良好的天然物质，可被视为棘阿米巴病治疗中的联合疗法。我们的研究表明，青蒿提取物可作为一种替代治疗工具。
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