Shafei Ayman, Ramzy Maggie M, Hegazy Abdelhares I, Husseny Ahmed K, El-Hadary Usama G, Taha Mazen M, Mosa Ali A
Biomedical Research Department, Armed Forces College of Medicine (AFCM), Cairo, Egypt.
Biochemistry Department, Faculty of Medicine, Minia University, Egypt.
Gene. 2018 Mar 20;647:235-243. doi: 10.1016/j.gene.2018.01.016. Epub 2018 Jan 6.
The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways. BPA has been associated with serious health effects in humans and wildlife. It elicits several endocrine disorders and plays a role in the pathogenesis of several hormone-dependent tumors such as breast, ovarian, prostate cancer and others. More complicate to this picture, its effects rely on several and diverse molecular and epigenetic mechanisms that converge upon endocrine and reproductive systems. The present review gives an overview of general hazards of BPA, its epigenetic modifications and the molecular mechanisms of BPA action in different types of cancers as the increase in information about responses and action mechanisms of BPA may bring a better understanding of the risks of BPA exposure in humans and provide an important platform on which human health can be improved.
内分泌干扰化学物（EDC）是一种外源性物质或混合物，它会改变内分泌系统的功能，从而在完整生物体中导致不良反应。双酚A（BPA）是最常见的内分泌干扰化学物之一，是一种用于生产水瓶、罐头和牙齿缝合材料的碳基合成化合物。已知它是一种外源性雌激素，因为它与雌激素受体相互作用，并通过雌激素受体依赖性信号通路充当激动剂或拮抗剂。双酚A已被证明会对人类和野生动物的健康产生严重影响。它会引发多种内分泌紊乱，并在几种激素依赖性肿瘤（如乳腺癌、卵巢癌、前列腺癌等）的发病机制中起作用。更复杂的是，其影响依赖于多种不同的分子和表观遗传机制，这些机制作用于内分泌和生殖系统。本综述概述了双酚A的一般危害、其表观遗传修饰以及双酚A在不同类型癌症中的作用分子机制，因为关于双酚A反应和作用机制的信息增加，可能会让人们更好地了解双酚A暴露对人类的风险，并为改善人类健康提供一个重要平台。
