用于治疗小直径肺转移瘤的915兆赫兹与2450兆赫兹微波消融系统的比较
A comparison between 915 MHz and 2450 MHz microwave ablation systems for the treatment of small diameter lung metastases.
作者信息
Vogl Thomas J, Roman Andrei, Nour-Eldin Nour-Eldin A, Hohenforst-Schmidt Wolfgang, Bednarova Iliana, Kaltenbach Benjamin
机构信息
Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany; Department of Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
出版信息
Diagn Interv Radiol. 2018 Jan-Feb;24(1):31-37. doi: 10.5152/dir.2018.17017.
PURPOSE
We aimed to retrospectively compare the local tumor control rates between low frequency (LF) and high frequency (HF) microwave ablation devices in the treatment of <3 cm lung metastases.
METHODS
A total of 36 patients (55 tumors) were treated with the LF system (915 MHz) and 30 patients (39 tumors) were treated with the HF system (2450 MHz) between January 2011 and March 2016. Computed tomography (CT) scans performed prior to and 24 hours after the ablation were used to measure the size of the ablation zone and to calculate the ablation margin. The subsequent CTs were used to detect local tumor progression. Possible predictive factors for local progression were analyzed. All patients had a minimum follow-up of 3 months with a median of 13.8 months for the LF group and 11.7 months for the HF group.
RESULTS
The ablation margin (P = 0.015), blood vessel proximity (P = 0.006), and colorectal origin (P = 0.029) were significantly associated with the local progression rate. The local progression rates were 36.3% for LF ablations and 12.8% for HF ablations. The 6, 12, and 18 months local progression-free survival rates were 79%, 65.2% and 53% for the LF group and 97.1%, 93.7%, and 58.4% for the HF group, with a significant difference between the survival curves (P = 0.048).
CONCLUSION
HF ablations resulted in larger ablation margins with fewer local progression compared with LF ablations.
目的
我们旨在回顾性比较低频（LF）和高频（HF）微波消融设备在治疗直径<3 cm肺转移瘤时的局部肿瘤控制率。
方法
2011年1月至2016年3月期间，共有36例患者（55个肿瘤）接受了LF系统（915 MHz）治疗，30例患者（39个肿瘤）接受了HF系统（2450 MHz）治疗。在消融前和消融后24小时进行的计算机断层扫描（CT）用于测量消融区大小并计算消融边缘。随后的CT用于检测局部肿瘤进展情况。分析了局部进展的可能预测因素。所有患者至少随访3个月，LF组的中位随访时间为13.8个月，HF组为11.7个月。
结果
消融边缘（P = 0.015）、血管接近程度（P = 0.006）和结直肠起源（P = 0.029）与局部进展率显著相关。LF消融的局部进展率为36.3%，HF消融的局部进展率为12.8%。LF组6个月、12个月和18个月的局部无进展生存率分别为79%、65.2%和53%，HF组分别为97.1%、93.7%和58.4%，生存曲线之间存在显著差异（P = 0.048）。
结论
与LF消融相比，HF消融产生的消融边缘更大，局部进展更少。
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