Liang Chaojie, Xu Yingchen, Ge Hua, Li Guangming, Wu Jixiang
Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Onco Targets Ther. 2017 Dec 21;11:47-57. doi: 10.2147/OTT.S151390. eCollection 2018.
Octamer-binding transcription factor 4 (OCT4) has been implicated in the development of hepatocellular carcinoma (HCC), although the findings are controversial. We conducted a meta-analysis to assess the correlation between OCT4 and the clinicopathological characteristics and the prognostic value in HCC.
An electronic search for relevant articles was conducted in PubMed, Cochrane Library, Web of Science, EMBASE database, Chinese CNKI, and Chinese WanFang database. Correlations between OCT4 expression and clinicopathological features and survival outcomes were analyzed. Pooled odds ratios and hazard ratios with 95% CIs were calculated using STATA 14.2 software.
A total of 10 trials with 985 patients were included. Positive OCT4 expression was correlated with tumor size, tumor numbers, differentiation, and TNM stage. OCT4 expression was not correlated with gender, age, hepatitis B surface antigen, alfa-fetoprotein, liver cirrhosis, vascular invasion, or tumor encapsulation. OCT4 expression was associated with poor 3- and 5-year overall survival, and disease-free survival rate.
OCT4 expression was associated with tumor size, tumor numbers, differentiation, and TNM stage in HCC. OCT4 may be a useful prognostic biomarker for HCC.
八聚体结合转录因子4（OCT4）与肝细胞癌（HCC）的发生发展有关，尽管研究结果存在争议。我们进行了一项荟萃分析，以评估OCT4与HCC临床病理特征之间的相关性及其预后价值。
在PubMed、Cochrane图书馆、科学网、EMBASE数据库、中国知网和中国万方数据库中进行相关文章的电子检索。分析OCT4表达与临床病理特征及生存结果之间的相关性。使用STATA 14.2软件计算合并比值比和风险比及95%置信区间。
共纳入10项试验，985例患者。OCT4阳性表达与肿瘤大小、肿瘤数量、分化程度和TNM分期相关。OCT4表达与性别、年龄、乙肝表面抗原、甲胎蛋白、肝硬化、血管侵犯或肿瘤包膜无关。OCT4表达与3年和5年总生存率及无病生存率低有关。
OCT4表达与HCC的肿瘤大小、肿瘤数量、分化程度和TNM分期有关。OCT4可能是HCC一个有用的预后生物标志物。
