Solum N O
Semin Hematol. 1985 Oct;22(4):289-302.
Studies on platelet membrane proteins during the past decade have defined a series of such components and their roles in key phenomena in hemostasis and thrombosis such as platelet adhesion and aggregation. Central among the membrane proteins is the glycoprotein group. At this time, several of these proteins have been characterized as to apparent molecular weights and subunit composition whereas sugar and amino acid composition and sequences await further studies for most of them. The absence of specific membrane glycoproteins in congenital bleeding diseases has helped to identify their functions as receptors for known ligands for binding reactions central to the hemostatic mechanism. Some of the membrane proteins may exist more or less loosely attached to each other on the surface of intact platelets, and this may be important for their functions.
在过去十年间，关于血小板膜蛋白的研究已明确了一系列此类成分及其在止血和血栓形成等关键现象（如血小板黏附和聚集）中的作用。膜蛋白中的核心是糖蛋白组。目前，其中几种蛋白已根据其表观分子量和亚基组成得以表征，而它们中大多数的糖和氨基酸组成及序列还有待进一步研究。先天性出血性疾病中特定膜糖蛋白的缺失有助于确定它们作为已知配体受体的功能，这些配体参与止血机制核心的结合反应。一些膜蛋白在完整血小板表面可能或多或少地松散结合在一起，这可能对它们的功能很重要。
