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Early Cord Metabolite Index and Outcome in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy.围产期窒息和缺氧缺血性脑病中早期脐带代谢物指标与结局
Neonatology. 2016;110(4):296-302. doi: 10.1159/000446556. Epub 2016 Aug 3.
2
Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia.大麻二酚与低温对新生仔猪急性缺氧缺血后短期脑损伤的影响。
Front Neurosci. 2016 Jul 12;10:323. doi: 10.3389/fnins.2016.00323. eCollection 2016.
3
Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy.在患有缺氧缺血性脑病的婴儿中,爆发抑制和间断性脑电图活动的血液动力学反应。
Neurophotonics. 2016 Jul;3(3):031408. doi: 10.1117/1.NPh.3.3.031408. Epub 2016 May 2.
4
Hypothermia reduces seizure burden and improves neurological outcome in severe hypoxic-ischemic encephalopathy: an observational study.低温可减轻重度缺氧缺血性脑病的癫痫发作负担并改善神经学转归:一项观察性研究。
Dev Med Child Neurol. 2016 Dec;58(12):1235-1241. doi: 10.1111/dmcn.13195. Epub 2016 Jul 22.
5
A thermoregulation model for hypothermic treatment of neonates.
Med Eng Phys. 2016 Sep;38(9):988-98. doi: 10.1016/j.medengphy.2016.06.018. Epub 2016 Jul 1.
6
A Qualitative Study of Physician Perspectives on Prognostication in Neonatal Hypoxic Ischemic Encephalopathy.一项关于医生对新生儿缺氧缺血性脑病预后判断观点的定性研究
J Child Neurol. 2016 Oct;31(11):1312-9. doi: 10.1177/0883073816656400. Epub 2016 Jul 4.
7
Computed tomography diagnosis of neonatal hypoxic ischemic encephalopathy combined with intracranial hemorrhage and clinical nursing treatment.新生儿缺氧缺血性脑病合并颅内出血的计算机断层扫描诊断及临床护理治疗
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2):511-5.
8
Endogenous hypothermic response to hypoxia reduces brain injury: Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice.内源性低温反应对缺氧的减少脑损伤:对新生儿缺氧缺血性脑病模型和治疗性低温的影响。
Exp Neurol. 2016 Sep;283(Pt A):264-75. doi: 10.1016/j.expneurol.2016.06.024. Epub 2016 Jun 25.
9
Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.新生儿缺氧缺血性脑病的低温治疗:美国国立儿童健康与人类发展研究所新生儿研究网络对该领域的贡献。
Semin Perinatol. 2016 Oct;40(6):385-390. doi: 10.1053/j.semperi.2016.05.009. Epub 2016 Jun 23.
10
The Thompson Encephalopathy Score and Short-Term Outcomes in Asphyxiated Newborns Treated With Therapeutic Hypothermia.接受治疗性低温治疗的窒息新生儿的汤普森脑病评分与短期预后
Pediatr Neurol. 2016 Jul;60:49-53. doi: 10.1016/j.pediatrneurol.2016.03.014. Epub 2016 Apr 1.

新生儿中、重度缺氧缺血性脑病的亚低温治疗

Mild Hypothermia Therapy for Moderate or Severe Hypoxicischemic Encephalopathy in Neonates.

作者信息

Liao Weihua, Xu Huiying, Ding Jing, Huang Hong

机构信息

Dept. of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Iran J Public Health. 2018 Jan;47(1):64-69.

PMID:29318119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5756602/
Abstract

BACKGROUND

To study the nursing method of mild hypothermia therapy for moderate or severe hypoxic-ischemic encephalopathy (HIE) in neonates.

METHODS

According to the inclusion and exclusion criteria, 48 patients were selected from Nanfang Hospital from December 2015 to October 2016 and randomly divided into the control group (n=24) and observation group (n=24). The control group received routine treatment and nursing, while the observation group received the same treatment as the control group combined with mild hypothermia treatment and nursing. The clinical effects were compared.

RESULTS

The total effective rate in the observation group was increased and mortality was decreased, and the differences were statistically significant (=0.029 and 0.033, respectively). The 28 d neonatal behavioral neurological assessment and nursing satisfaction scores in the observation group were higher than those in the control group, and the differences were statistically significant (=0.017 and 0.008, respectively).

CONCLUSION

Mild hypothermia therapy for moderate or severe HIE in neonates is safe and effective, and the correct nursing method is important for guaranteeing proper clinical treatment.

摘要

背景

探讨新生儿中重度缺氧缺血性脑病(HIE)亚低温治疗的护理方法。

方法

根据纳入和排除标准,选取2015年12月至2016年10月南方医院收治的48例患者,随机分为对照组(n = 24)和观察组(n = 24)。对照组给予常规治疗和护理,观察组在对照组治疗基础上联合亚低温治疗及护理。比较两组临床疗效。

结果

观察组总有效率提高,死亡率降低,差异有统计学意义(分别为=0.029和0.033)。观察组28 d新生儿行为神经评分及护理满意度评分均高于对照组,差异有统计学意义(分别为=0.017和0.008)。

结论

新生儿中重度HIE亚低温治疗安全有效,正确的护理方法对保证临床治疗效果至关重要。