Wu Hongwei, Liu Gang, Yang Xia, Liu Qing, Li Zhenguang
Department of Newborn Medicine, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China.
Exp Ther Med. 2019 Sep;18(3):2194-2198. doi: 10.3892/etm.2019.7768. Epub 2019 Jul 12.
The effect of mild hypothermia on the expression of interleukin (IL)-10 and IL-18 in neonates with hypoxic ischemic encephalopathy was investigated. A retrospective analysis was performed on 97 neonates with hypoxic-ischemic encephalopathy (HIE) admitted to the neonatal intensive care unit of Xuzhou Children's Hospital, Xuzhou Medical University from September 2016 to August 2018. Of these patients, 54 with mild hypothermia were included in the experimental group (moderate + severe), and 43 patients who received conventional therapy were included in the control group (moderate + severe). The effect of mild hypothermia on IL-10 and IL-18 expression levels was analyzed, and the relationship between IL-10, IL-18 and disease severity in children with hypoxic ischemic encephalopathy was analyzed. The concentration of IL-10 in the experimental group was significantly lower than that in the control group at 1, 2, 3 and 5 days (P<0.05). The concentration of IL-18 in the experimental group was significantly lower than that in the control group at the 2, 3 and 5 days (P<0.05). NBNA scores of the experimental group were significantly higher than those of the control group at 14 and 28 days after birth (P<0.05). Before treatment, the expression levels of IL-10 and IL-18 in severe children were significantly higher than those in moderate children (P<0.05). IL-10 was positively correlated with the severity of the disease (r=0.521, P<0.05), and IL-18 was also positively correlated with the severity of the disease (r=0.616 P<0.05). Mild hypothermia treatment can effectively improve the neurological function of children with HIE, reduce the expression of IL-10 and IL-18 in serum, and inhibit the inflammatory response. Therefore, the expression of IL-10 and IL-18 was positively correlated with the severity of disease in children with HIE, and could be used as an indicator to judge the severity of HIE.
研究了亚低温对缺氧缺血性脑病新生儿白细胞介素（IL）-10和IL-18表达的影响。对2016年9月至2018年8月在徐州医科大学附属徐州儿童医院新生儿重症监护病房收治的97例缺氧缺血性脑病（HIE）新生儿进行回顾性分析。其中，54例接受亚低温治疗的患儿纳入实验组（中度+重度），43例接受常规治疗的患儿纳入对照组（中度+重度）。分析亚低温对IL-10和IL-18表达水平的影响，并分析IL-10、IL-18与缺氧缺血性脑病患儿疾病严重程度的关系。实验组在第1、2、3和5天IL-10浓度显著低于对照组（P<0.05）。实验组在第2、3和5天IL-18浓度显著低于对照组（P<0.05）。实验组出生后14天和28天的NBNA评分显著高于对照组（P<0.05）。治疗前，重度患儿IL-10和IL-18表达水平显著高于中度患儿（P<0.05）。IL-10与疾病严重程度呈正相关（r=0.521，P<0.05），IL-18也与疾病严重程度呈正相关（r=0.616，P<0.05）。亚低温治疗可有效改善HIE患儿的神经功能，降低血清中IL-10和IL-18的表达，抑制炎症反应。因此，IL-10和IL-18的表达与HIE患儿疾病严重程度呈正相关，可作为判断HIE严重程度的指标。
