Satomura Atsushi, Fujita Takayuki, Maruyama Takashi, Hamada Hiroaki, Nozawa Yukinari, Takayama Eiichi, Maruyama Toshiharu, Nakayama Tomohiro
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
Division of Nephrology, hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
Open Med (Wars). 2017 Dec 29;12:468-473. doi: 10.1515/med-2017-0065. eCollection 2017.
Myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis (MPO-AAV) does not usually involve large vessels, such as the aorta. However, we experienced three cases having an aortic aneurysm as a complication of MPO-AAV with renal insufficiency. In one patient it involved the onset of descending aortic dissection during treatment for MPO-AAV; another two patients had an abdominal aortic aneurysm at the time of our diagnosis of MPO-AAV. Although we found no pathological evidence in our patients, MPO-AAV might result in large vessel inflammation. Therefore, we suggest that patients with MPO-AAV should be examined by computed tomography scan to check for the presence of an aortic aneurysm.
髓过氧化物酶-抗中性粒细胞胞浆抗体相关血管炎（MPO-AAV）通常不累及大血管，如主动脉。然而，我们遇到了3例因MPO-AAV并发肾功能不全而出现主动脉瘤的病例。其中1例患者在MPO-AAV治疗期间发生降主动脉夹层；另外2例患者在我们诊断MPO-AAV时已有腹主动脉瘤。尽管我们在患者中未发现病理证据，但MPO-AAV可能导致大血管炎症。因此，我们建议对MPO-AAV患者进行计算机断层扫描检查，以排查主动脉瘤的存在。
