Niu Fu-Xing, Lu Qian, Bu Yi-Fan, Liu Jian-Zhong
Biotechnology Research Center and Biomedical Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Synth Syst Biotechnol. 2017 Aug 30;2(3):167-175. doi: 10.1016/j.synbio.2017.08.001. eCollection 2017 Sep.
Isoprenoids are the most abundant and highly diverse group of natural products. Many isoprenoids have been used for pharmaceuticals, nutraceuticals, flavors, cosmetics, food additives and biofuels. Carotenoids and isoprenoid-based biofuels are two classes of important isoprenoids. These isoprenoids have been produced microbially through metabolic engineering and synthetic biology efforts. Herein, we briefly review the engineered biosynthetic pathways in well-characterized microbial systems for the production of carotenoids and several isoprenoid-based biofuels.
类异戊二烯是天然产物中最为丰富且种类繁多的一类。许多类异戊二烯已被用于制药、营养保健品、香料、化妆品、食品添加剂和生物燃料。类胡萝卜素和基于类异戊二烯的生物燃料是两类重要的类异戊二烯。通过代谢工程和合成生物学的努力，已在微生物中生产出这些类异戊二烯。在此，我们简要综述了在特征明确的微生物系统中用于生产类胡萝卜素和几种基于类异戊二烯的生物燃料的工程化生物合成途径。
