Altmann S, Regul M, Zeidler H, Hartmann F
Z Rheumatol. 1985 Mar-Apr;44(2):64-71.
Normal bovine synovial fluid and synovial effusions in human non-inflammatory joint diseases do not show any decrease of viscosity for a long period of time during imposed shear loading, as is required for thixotropy. This observation is based on two different methods of measurement; the "hysteresis loop" method and the recording of the shear stress-time curve. Inflammatory synovial fluids--particularly from patients with rheumatoid arthritis and a high concentration of fibrinogen--form a visible gel after 6 to 20 hours of rest. Those gels show a hysteresis loop typical for thixotropy and a decrease of viscosity with the duration of shear loading. Due to the shearing in the rheometer precipitation occurs and fibrin clots appear. The appearance of fibrin clots induced by mechanical shear loading not known until now, can be discussed with regard to its possible participation in the symptom of morning stiffness, in the formation of rice bodies and in the destruction of joint cartilage in rheumatoid arthritis.
正常牛滑液以及人类非炎性关节疾病中的滑液渗出物，在施加剪切负荷的长时间过程中，不会像触变性所要求的那样出现粘度降低的情况。这一观察结果基于两种不同的测量方法：“滞后回线”法和剪切应力-时间曲线记录法。炎性滑液——尤其是来自类风湿关节炎患者且纤维蛋白原浓度较高的滑液——在静置6至20小时后会形成可见凝胶。这些凝胶呈现出典型的触变性滞后回线，并且随着剪切负荷持续时间的增加粘度降低。由于流变仪中的剪切作用，会发生沉淀并出现纤维蛋白凝块。机械剪切负荷诱导纤维蛋白凝块的出现此前尚不为人所知，鉴于其可能参与类风湿关节炎晨僵症状、米粒体形成以及关节软骨破坏，对此可进行讨论。
