Carsons S, Mosesson M W, Diamond H S
Arthritis Rheum. 1981 Oct;24(10):1261-7.
Fibronectin, a high molecular weight glycoprotein that binds to glycosaminoglycans, fibrinogen or fibrin, and collagen, was identified and quantitated in synovial fluid from patients with various rheumatic diseases. Fibronectin concentration was significantly higher in synovial fluids from patients with rheumatoid arthritis (RA) (697 microgram/ml) than in other synovial fluids. In RA, synovial fluid fibronectin concentration exceeded that in plasma and did not directly correlate with synovial fluid concentrations of albumin, total protein, or fibrinogen. Synovial fluid fibronectin concentration correlated directly with synovial fluid white blood cell count (r = 0.50, P less than 0.005). Fibronectin was present in cryoprotein formed from four rheumatoid synovial fluids.
纤连蛋白是一种高分子量糖蛋白，可与糖胺聚糖、纤维蛋白原或纤维蛋白以及胶原蛋白结合。在患有各种风湿性疾病患者的滑液中对其进行了鉴定和定量。类风湿关节炎（RA）患者滑液中的纤连蛋白浓度（697微克/毫升）显著高于其他滑液。在类风湿关节炎中，滑液纤连蛋白浓度超过血浆中的浓度，且与滑液中白蛋白、总蛋白或纤维蛋白原的浓度无直接相关性。滑液纤连蛋白浓度与滑液白细胞计数直接相关（r = 0.50，P < 0.005）。纤连蛋白存在于由四种类风湿滑液形成的冷沉淀蛋白中。
