Centre de recherche en organogenese experimentale de l'Université Laval/LOEX, Centre de recherche du CHU de Quebec, Quebec, Canada.
Department of Surgery, Faculty of Medicine, Universite Laval, Quebec, Canada.
J Cell Physiol. 2018 Aug;233(8):5550-5563. doi: 10.1002/jcp.26426. Epub 2018 Mar 1.
Longtime considered as inert cellular debris, microvesicles (MVs) have gained tremendous attention in the past decade. MVs are 100-1000 nm vesicles released into the extracellular environment by the outward budding and fission of the plasma membrane. They are now regarded as essential mediators of cell-to-cell interactions in a variety of physiological and pathological processes. In this review, we discuss the increasingly recognized contribution of MVs to the biology of wound healing. We highlight current concepts relating to the biogenesis and mode of action of MVs. We discuss the emerging roles of MVs in the hemostatic, inflammatory, proliferative, and remodeling phases of the injury-repair response. In doing so, we provide a new perspective on the dynamics of intercellular communication involved in skin homeostasis.
长期以来被认为是无活性的细胞碎片，微泡（MVs）在过去十年中受到了极大的关注。MVs 是由质膜向外出芽和裂变而释放到细胞外环境中的 100-1000nm 的囊泡。它们现在被认为是各种生理和病理过程中细胞间相互作用的重要介质。在这篇综述中，我们讨论了 MVs 对创伤愈合生物学的日益认识到的贡献。我们强调了与 MVs 的生物发生和作用模式相关的当前概念。我们讨论了 MVs 在止血、炎症、增殖和损伤修复反应的重塑阶段的新兴作用。这样，我们就参与皮肤动态平衡的细胞间通讯提供了一个新的视角。
