铜催化的硝基炔烃的自由基二氟烷基化和氧化环化反应构建 C2-四取代的吲哚啉-3-酮。
Copper-Catalyzed Radical Difluoroalkylation and Redox Annulation of Nitroalkynes for the Construction of C2-Tetrasubstituted Indolin-3-ones.
机构信息
Institute of Next Generation Matter Transformation, Fujian Provincial Key Laboratory of Biochemical Technology, College of Chemical Engineering, College of Materials Science and Engineering at Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China.
出版信息
Org Lett. 2018 Jan 19;20(2):393-396. doi: 10.1021/acs.orglett.7b03678. Epub 2018 Jan 10.
An efficient and convenient method with wide applicability for the synthesis of C2-tetrasubstituted indolin-3-ones via copper-catalyzed redox cycloisomerization of nonprefunctionalized nitroalkynes has been developed. This protocol features simple operation, readily available starting materials, good functional group tolerance, broad scope, and diboron as the reductant.
一种高效、便捷的方法，通过铜催化的非预官能化硝基炔的氧化还原环异构化，合成 C2-四取代吲哚啉-3-酮。该方法具有操作简单、原料易得、官能团容忍性好、适用范围广、二硼为还原剂等特点。
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