L减轻糖尿病肾病——抑制链脲佐菌素-烟酰胺诱导的糖尿病大鼠中晚期糖基化终产物的积累。

L. attenuates diabetic nephropathy inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats.

作者信息

Kaur Navpreet, Kishore Lalit, Singh Randhir

机构信息

Maharishi Markandeshwar College of Pharmacy, India.

出版信息

J Tradit Complement Med. 2017 Jun 21;8(1):226-238. doi: 10.1016/j.jtcme.2017.06.004. eCollection 2018 Jan.

The present study was aimed to evaluate advanced glycation end products (AGEs) inhibitory activity of alcohol and hydro-alcohol extract (DAE and DHE) of L. (Family: Dilleniaceae) and its potential in treatment of diabetic nephropathy by targeting markers of oxidative stress. . was evaluated for its inhibitory activity against formation of AGEs by using bovine serum albumin. Diabetes was induced in male Wistar rats by streptozotocin (65 mg/kg ..) 15 min after nicotinamide (230 mg/kg, ..) administration. Diabetic rats were treated with different doses of extracts (100, 200 and 400 mg/kg) to analyze their nephroprotective effect. Tissue antioxidant enzymes level was measured along with the formation of AGEs in kidney to assess the effect of . in ameliorating oxidative stress. . showed significant inhibition of AGEs formation . . produced significant attenuation in the glycemic status, renal parameter, lipid profile and level of antioxidant enzymes proving efficacy in diabetic nephropathy. Moreover, . produced significant reduction in the formation of AGEs in kidneys. The present study concludes that . as a possible therapeutic agent against diabetic nephropathy.

本研究旨在评估五桠果科植物[植物名称未给出，原文为L. (Family: Dilleniaceae)]的乙醇提取物和水醇提取物（DAE和DHE）对晚期糖基化终产物（AGEs）的抑制活性，以及通过靶向氧化应激标志物来治疗糖尿病肾病的潜力。使用牛血清白蛋白评估了[提取物名称未给出，原文为. ，结合前文推测是DAE和DHE]对AGEs形成的抑制活性。在给予烟酰胺（230 mg/kg，腹腔注射）15分钟后，通过链脲佐菌素（65 mg/kg，腹腔注射）诱导雄性Wistar大鼠患糖尿病。用不同剂量的提取物（100、200和400 mg/kg）治疗糖尿病大鼠，以分析它们的肾保护作用。测量组织抗氧化酶水平以及肾脏中AGEs的形成，以评估[提取物名称未给出，原文为. ，结合前文推测是DAE和DHE]在改善氧化应激方面的作用。[提取物名称未给出，原文为. ，结合前文推测是DAE和DHE]对AGEs的形成显示出显著抑制作用。[提取物名称未给出，原文为. ，结合前文推测是DAE和DHE]在血糖状态、肾脏参数、血脂谱和抗氧化酶水平方面产生显著改善，证明其对糖尿病肾病有效。此外，[提取物名称未给出，原文为. ，结合前文推测是DAE和DHE]使肾脏中AGEs的形成显著减少。本研究得出结论，[提取物名称未给出，原文为. ，结合前文推测是DAE和DHE]作为一种可能的抗糖尿病肾病治疗药物。