, a pharmacologically effective alternative for in an Ayurvedic preparation, .

(Fabaceae) is a prime ingredient in , a well-known Ayurvedic preparation for gynecological ailments. Due to scarcity, adulteration or substitution of related raw drugs is a common practice in its preparation. The bark of (Roxb. ex DC.) Harms, morphologically similar to (Asoka) is a widely used substitute. The present study aimed to evaluate the pharmacological effectiveness of as an alternative for in by determining the inhibitory effect of estrogen induced uterus endometrial thickening in immature female rats. was prepared using and with the substitute, as per Ayurvedic Pharmacopeia. Uterus endometrial thickening was induced by the administration of estradiol (20 μg/kg b. wt, i.p) to 8-day-old rats for 5 alternate days. On day 16, following estradiol administration, the serum estrogen level was found elevated to 156.5 ± 8 pg/ml from the normal value 32.4 ± 5 pg/ml and consequently increased the thickness of uterus endometrium from 16.7 ± 1.4 to 75.2 ± 15.3 μm. Upon oral administration of 400 μl/kg b. wt (ASA) and made with (AKP), the thickening was reduced to 42.5 ± 12.7 and 47.1 ± 10.5 μm and the estrogen level diminished to 102.6 ± 10 and 97.3 ± 8 pg/ml, respectively. also reduced the chronic/acute inflammations in mice and improved the antioxidant status of rats. No toxic symptom was observed in the animals by the treatment of . The study supports the use of as an alternative to in and gives a scientific validation for in gynecological ailments.