暴发高死亡率嗉囊炎中的一种新型杯状病毒（小 RNA 病毒科）。
A novel passerivirus (family Picornaviridae) in an outbreak of enteritis with high mortality in estrildid finches (Uraeginthus sp.).
机构信息
Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary.
Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
出版信息
Arch Virol. 2018 Apr;163(4):1063-1071. doi: 10.1007/s00705-017-3699-0. Epub 2018 Jan 10.
An enteric outbreak with high mortality (34/52, 65.4%) was recorded in 2014 in home-reared estrildid finches (Estrildidae) in Hungary. A novel passerivirus was identified in a diseased violet-eared waxbill using viral metagenomics and confirmed by RT-(q)PCR. The complete genome of finch picornavirus strain waxbill/DB01/HUN/2014 (MF977321) showed the highest amino acid sequence identity of 38.9%, 61.6%, 69.6% in P1, 2C and 3CD, respectively, to passerivirus A1 (GU182406). A high viral load (6.58 × 10 genomic copies/ml) was measured in a cloacal specimen and in the tissues (spinal cord, lung, and the intestines) of two additional affected finches. In addition to intestinal symptoms (diarrhoea), the presence of extra-intestinal virus suggests a generalized infection in this fatal disease, for which the passerivirus might be a causative agent.
2014 年，匈牙利家养燕雀目鸟类（Estrildidae）中爆发了一起死亡率高（34/52，65.4%）的肠道疾病。一种新型的禽肠道正黏病毒在患病的紫耳彩鹀中使用病毒宏基因组学进行鉴定，并通过 RT-（q）PCR 得到证实。雀形目小核糖核酸病毒科 Finch picornavirus 株 waxbill/DB01/HUN/2014（MF977321）的完整基因组，在 P1、2C 和 3CD 分别显示出与禽肠道正黏病毒 A1（GU182406）最高的氨基酸序列同一性为 38.9%、61.6%和 69.6%。在一个泄殖腔标本和另外两只受感染燕雀的组织（脊髓、肺和肠道）中检测到高病毒载量（6.58×10 个基因组拷贝/ml）。除了肠道症状（腹泻）外，肠外病毒的存在表明在这种致命疾病中存在全身性感染，禽肠道正黏病毒可能是其病原体。
Zotero 插件