匈牙利家养普通鹌鹑（Coturnix coturnix）中新型小核糖核酸病毒。
Novel picornavirus in domesticated common quail (Coturnix coturnix) in Hungary.
机构信息
Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, Pécs 7623, Hungary.
出版信息
Arch Virol. 2012 Mar;157(3):525-30. doi: 10.1007/s00705-011-1192-8. Epub 2011 Dec 15.
This study reports the detection of a novel picornavirus in domesticated common quail (Coturnix coturnix) in Hungary. The 8159-nucleotide (nt)-long RNA genome of this virus, named quail picornavirus (QPV1-HUN/2010; JN674502), shows only 43%, 39% and 47% amino acid (aa) identity in the P1 (857 aa), P2 (458 aa) and P3 (777 aa) coding regions respectively, to the closest reference, avian sapelovirus. The 5'UTR contains a variant type IV IRES with a 20-nt-long apical "8"-like structure that is conserved in avian-origin and seal picornaviruses. The 390-aa-long L protein is cysteine rich and encodes two copies of a 34-aa-long repeat motif. Quail picornavirus represents a novel picornavirus species and perhaps a novel genus.
本研究报告了在匈牙利家养普通鹌鹑（Coturnix coturnix）中检测到一种新型微小 RNA 病毒。该病毒的 8159 个核苷酸（nt）长的 RNA 基因组被命名为鹌鹑微小 RNA 病毒（QPV1-HUN/2010；JN674502），在 P1（857 个 aa）、P2（458 个 aa）和 P3（777 个 aa）编码区，其与最接近的参考病毒——禽沙波病毒的氨基酸（aa）同一性分别为 43%、39%和 47%。5'UTR 包含一个变体 IV 型 IRES，具有一个 20-nt 长的顶端“8”样结构，在禽源和海豹微小 RNA 病毒中保守。长 390 个 aa 的 L 蛋白富含半胱氨酸，编码两个 34 个 aa 长的重复基序。鹌鹑微小 RNA 病毒代表一种新型微小 RNA 病毒，可能是一个新的属。
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