星状纤维介孔二氧化硅与合成双链RNA类似物在癌症免疫治疗中的协同作用。
Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy.
作者信息
Wang Xiupeng, Li Xia, Ito Atsuo, Sogo Yu, Watanabe Yohei, Hashimoto Kaoru, Yamazaki Atsushi, Ohno Tadao, Tsuji Noriko M
机构信息
Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
出版信息
Chem Commun (Camb). 2018 Jan 25;54(9):1057-1060. doi: 10.1039/c7cc08222c.
Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.
星状纤维介孔二氧化硅纳米球在体外显著提高了癌症抗原的细胞摄取率以及骨髓来源树突状细胞的成熟度。此外，聚肌苷酸:聚胞苷酸（poly(I:C)）与星状纤维介孔二氧化硅纳米球的组合显著降低了抗肿瘤免疫所需的聚肌苷酸:聚胞苷酸剂量，从而为聚肌苷酸:聚胞苷酸在癌症免疫治疗中的未来临床应用开辟了新机遇。
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