Gater David R, Farkas Gary J, Berg Arthur S, Castillo Camilo
a Department of Physical Medicine and Rehabilitation , Penn State College of Medicine , Hershey , Pennsylvania.
b Department of Public Health Sciences , Penn State College of Medicine , Hershey , Pennsylvania.
J Spinal Cord Med. 2019 Jan;42(1):86-93. doi: 10.1080/10790268.2017.1423266. Epub 2018 Jan 11.
CONTEXT/OBJECTIVE: Recent literature would suggest the prevalence of metabolic syndrome in persons with spinal cord injury (SCI) is higher than that of the general population, although no large cohorts have yet been reported. Part of the controversy relates to the differing definitions provided for metabolic syndrome and the characterization of obesity in persons with SCI.
DESIGN/PARTICIPANTS: The current retrospective investigation represents a cross-sectional cohort of 473 veterans with SCI from a single center in the mid-Atlantic region of the United States for whom modified International Diabetes Federation (IDF) criterion variables for the metabolic syndrome were available in the computerized personal record system (CPRS).
These variables included a surrogate marker of obesity appropriate to SCI (Body Mass Index (BMI) ≥ 22 kg/m), as well as indicators of diabetes, dyslipidemia and hypertension.
Over 57% of the veterans assessed were determined to have metabolic syndrome by modified IDF criteria, including 76.7% with BMI ≥ 22 kg/m, 55.1% with or under treatment for hypertension, 49.7% with or previously diagnosed with diabetes mellitus, and 69.7% with or under treatment for high density lipoprotein (HDL) cholesterol under 40 mg/dl.
Metabolic syndrome and its constituent components appear to be more prevalent in veterans with SCI than in the general population, suggesting a greater need for identification and treatment interventions in this specialty population.
背景/目的：近期文献表明，脊髓损伤（SCI）患者中代谢综合征的患病率高于普通人群，尽管尚未有大型队列研究报告。部分争议涉及代谢综合征的不同定义以及SCI患者肥胖的特征。
设计/参与者：本次回顾性调查是对来自美国大西洋中部地区一个中心的473名患有SCI的退伍军人进行的横断面队列研究，在计算机化个人记录系统（CPRS）中可获取这些患者代谢综合征的改良国际糖尿病联盟（IDF）标准变量。
这些变量包括适用于SCI的肥胖替代指标（体重指数（BMI）≥22 kg/m²），以及糖尿病、血脂异常和高血压的指标。
根据改良的IDF标准，超过57%的接受评估的退伍军人被判定患有代谢综合征，其中BMI≥22 kg/m²的占76.7%，正在接受或曾接受高血压治疗的占55.1%，曾被诊断患有糖尿病的占49.7%，正在接受或曾接受高密度脂蛋白（HDL）胆固醇低于40 mg/dl治疗的占69.7%。
代谢综合征及其组成成分在患有SCI的退伍军人中似乎比在普通人群中更为普遍，这表明在这一特殊人群中更需要进行识别和治疗干预。
