杀生剂的杀病毒效率比较分析

A comparative analysis of virucidal efficiency of biocide agents.

作者信息

Nosik Nikolay N, Nosik D N, Chizhov A I

出版信息

Vopr Virusol. 2017;62(1):41-5.

Abstract

The main groups of biocide agents used for inactivation of bacteria and viruses were studied for their virucidal activity against enveloped (HIV, viral hepatitis C, influenza virus A) and non-enveloped viruses (poliovirus, adenovirus). Their efficiency was analyzed. Quarterly ammonium compounds (QAC) themselves are not able to properly inactivate non-enveloped viruses. However, they can be successfully applied in combination with other biocides (guanidines, aldehydes). Effective composition of QAC with amines and guanidines provided inactivation of viruses (4.0 lgTCID50) in concentrations of 0.166-0.280% for non-enveloped viruses and 0.080-00.185% for enveloped viruses. The combination of QAC with aldehydes is especially effective (0.04-0.64% for non-enveloped viruses). The virucidal efficiency does not directly depend on the QAC concentration in the chemical disinfectants.

摘要

对用于灭活细菌和病毒的主要杀菌剂类别进行了研究，考察其对包膜病毒（艾滋病毒、丙型肝炎病毒、甲型流感病毒）和非包膜病毒（脊髓灰质炎病毒、腺病毒）的杀病毒活性。分析了它们的效果。季铵化合物（QAC）本身无法有效灭活非包膜病毒。然而，它们可与其他杀菌剂（胍类、醛类）成功联用。QAC与胺类和胍类的有效组合，对于非包膜病毒，在浓度为0.166 - 0.280%时可灭活病毒（4.0 lgTCID50），对于包膜病毒，在浓度为0.080 - 0.185%时可灭活病毒。QAC与醛类的组合尤其有效（对于非包膜病毒为0.04 - 0.64%）。化学消毒剂中的杀病毒效率并不直接取决于QAC的浓度。