Yan Yong, Guo Tuan-Mao, Zhu Chao
a The Second Department of Orthopaedics, Shaanxi Traditional Chinese Medicine Hospital, Xi'an 710003, P.R. China.
b The Second Department of Orthopaedics, Xianyang Central Hospital, Xianyang 712000, P.R. China.
Biochem Cell Biol. 2018 Aug;96(4):450-456. doi: 10.1139/bcb-2017-0267. Epub 2018 Jan 11.
This study was conducted to investigate the correlation between serum levels of proinflammatory cytokines and the clinical efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with ankylosing spondylitis (AS).
A total of 148 patients with AS were selected and received NSAID treatment. ELISA was used to assess cytokine levels, and patients were assigned into the following groups: positively effective; effective; moderately effective; and ineffective. Spearman and Pearson correlation analyses were used for correlation analysis.
The erythrocyte sedimentation rates (ESR), C-reactive protein (CRP) levels, and immunoglobulin A (IgA) levels of the case group after NSAID treatment were markedly lower than those before NSAID treatment. After treatment, the levels of interleukin (IL)-6, IL-17, and tumor necrosis factor (TNF)-α were markedly reduced, while IL-10 levels increased in the positively effective, effective, and moderately effective groups, and IL-12 levels decreased in the positively effective and effective groups. In addition, the levels of IL-6 and TNF-α were correlated with a greater number in the efficacy indexes and clinical parameters, followed by IL-10 levels, while the levels of IL-17 and IL-12 had relatively weaker correlations with these indexes and parameters.
NSAIDs could promote the clinical efficacy of treatment for ankylosing spondylitis by regulating serum levels of proinflammatory cytokines.
本研究旨在探讨强直性脊柱炎（AS）患者血清促炎细胞因子水平与非甾体抗炎药（NSAIDs）临床疗效之间的相关性。
选取148例AS患者并给予NSAIDs治疗。采用酶联免疫吸附测定法（ELISA）评估细胞因子水平，将患者分为以下几组：显效；有效；中效；无效。采用Spearman和Pearson相关分析进行相关性分析。
NSAIDs治疗后病例组的红细胞沉降率（ESR）、C反应蛋白（CRP）水平和免疫球蛋白A（IgA）水平明显低于NSAIDs治疗前。治疗后，显效、有效和中效组的白细胞介素（IL）-6、IL-17和肿瘤坏死因子（TNF）-α水平明显降低，而IL-10水平升高，显效和有效组的IL-12水平降低。此外，IL-6和TNF-α水平与更多的疗效指标和临床参数相关，其次是IL-10水平，而IL-17和IL-12水平与这些指标和参数的相关性相对较弱。
NSAIDs可通过调节血清促炎细胞因子水平促进强直性脊柱炎的临床治疗效果。
