State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun, 130022, P. R. China.
Department of Radiology, The Second Hospital of Jilin University, Changchun, 130041, P. R. China.
Small. 2018 Feb;14(7). doi: 10.1002/smll.201702431. Epub 2018 Jan 11.
Design of new nanoagents that intrinsically have both diagnostic imaging and therapeutic capabilities is highly desirable for personalized medicine. In this work, a novel nanotheranostic agent is fabricated based on polydopamine (PDA)-functionalized Co-P nanocomposites (Co-P@PDA) for magnetic resonance imaging (MRI)-guided combined photothermal therapy and chemotherapy. The ultrahigh relaxivity of 224.61 mm s can enable Co-P@PDA to be applied as an excellent contrast agent for MRI in vitro and in vivo, providing essential and comprehensive information for tumor clinical diagnosis. Moreover, Co-P@PDA exhibit excellent photothermal performance owing to the strong near-infrared (NIR) absorbance of both Co-P nanocomposite and PDA. Highly effective ablation of tumors is achieved in a murine tumor model because the NIR laser not only induces photothermal effects but also triggers the chemotherapeutic drug on-demand release, which endows the Co-P@PDA with high curative effects but little toxicity and few side effects. These findings demonstrate that Co-P@PDA are promising agents for highly effective and precise antitumor treatment and warrant exploration as novel theranostic nanoagents with good potential for future clinical translation.
设计兼具诊断成像和治疗功能的新型纳米制剂对于个性化医疗来说是非常理想的。在这项工作中，基于聚多巴胺（PDA）功能化 Co-P 纳米复合材料（Co-P@PDA）制备了一种新型的治疗诊断一体化纳米制剂，用于磁共振成像（MRI）引导的光热治疗和化学治疗联合治疗。超高的弛豫率（224.61mm/s）使得 Co-P@PDA 可以作为 MRI 的优异造影剂用于体外和体内，为肿瘤临床诊断提供必要且全面的信息。此外，由于 Co-P 纳米复合材料和 PDA 都具有很强的近红外（NIR）吸收能力，因此 Co-P@PDA 表现出优异的光热性能。在小鼠肿瘤模型中实现了高效的肿瘤消融，因为近红外激光不仅能引发光热效应，还能按需触发化疗药物的释放，使 Co-P@PDA 具有高效的治疗效果，同时毒性和副作用较小。这些研究结果表明，Co-P@PDA 是一种很有前途的高效、精确抗肿瘤治疗药物，有望作为新型治疗诊断一体化纳米制剂，具有良好的临床转化前景。
