Rauls D O, Moreno A J, Gregory G, Penney L L, Parker G, Collins J, Daniels J R
J Nucl Med. 1985 Nov;26(11):1331-4.
The cytotoxic chemotherapeutic agent doxorubicin was found to acutely decrease platelet survival times in beagle dogs as determined using platelets labeled with [111In]oxine. Recovery was rapid, with platelet survival times returning to normal within 3 wk of cessation of treatment. Doxorubicin (1.5 mg/kg i.v. every 3 wk for a total of four doses) also delayed the return of platelet survival times to normal when given to beagle dogs following placement of thoracoabdominal aortic Dacron grafts. It is not known whether or not this may have clinical significance.
细胞毒性化疗药物阿霉素被发现可使比格犬的血小板存活时间急剧缩短，这是通过使用[111铟]奥克辛标记的血小板来测定的。恢复迅速，血小板存活时间在停止治疗后3周内恢复正常。在给比格犬植入胸腹主动脉涤纶移植物后给予阿霉素（每3周静脉注射1.5毫克/千克，共四剂），也会延迟血小板存活时间恢复正常。尚不清楚这是否具有临床意义。
