Pirogov Russian National Research Medical University, Moscow 117997, Russia; National Medical Research Center for Cardiology, Moscow 121552, Russia.
Pirogov Russian National Research Medical University, Moscow 117997, Russia; National Medical Research Center for Cardiology, Moscow 121552, Russia.
J Neuroimmunol. 2018 Apr 15;317:67-76. doi: 10.1016/j.jneuroim.2018.01.005. Epub 2018 Jan 5.
MiRNAs were shown to participate in development of autoimmune inflammatory process in multiple sclerosis (MS). To investigate miRNAs involvement in relapse-remission MS course, we analyzed expression of immune-related miRNAs in PBMC of treatment-naïve relapsing and remitting MS patients and healthy controls. The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed; when apply gender stratification, miR-223-3p and miR-379-5p were upregulated only in men. Therefore, miRNAs play essential role in maintaining stable MS course and this process has certain gender-specific differences.
miRNAs 被证明参与了多发性硬化症（MS）自身免疫炎症过程的发展。为了研究 miRNAs 在复发缓解型 MS 病程中的参与，我们分析了未经治疗的复发缓解型 MS 患者和健康对照者 PBMC 中免疫相关 miRNAs 的表达。与复发相比，我们观察到 miR-126-3p、miR-146b-5p、miR-155、miR-196a-5p、miR-21-5p、miR-223-3p、miR-326 和 miR-379-5p 在缓解期的上调；当进行性别分层时，仅在男性中观察到 miR-223-3p 和 miR-379-5p 的上调。因此，miRNAs 在维持稳定的 MS 病程中发挥着重要作用，而这一过程具有一定的性别特异性差异。
