Edward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri.
Mo Med. 2023 Sep-Oct;120(5):367-373.
Charged ions and ion channels play a critical role in regulating the electrical activities of excitable cells. This review discusses the principles of ion channel regulation in the time domain, as well as the diseases that can arise from channel dysfunction and disturbances in ionic balance. Ion channel signaling is a dynamic process that is essential for various physiological functions, including pain sensation, motor control, and the body's response to stress, such as fight-or-flight response.
带电离子和离子通道在调节可兴奋细胞的电活动方面起着至关重要的作用。本综述讨论了离子通道在时间域内的调节原理，以及通道功能障碍和离子平衡紊乱可能导致的疾病。离子通道信号转导是一个动态过程，对于各种生理功能至关重要，包括疼痛感知、运动控制和身体对压力的反应，如战斗或逃跑反应。
