Laboratory for Systems Neurophysiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Laboratory for Neural Computation and Adaptation, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Science. 2018 Jan 12;359(6372):213-218. doi: 10.1126/science.aao3898.
An animal's awareness of its location in space depends on the activity of place cells in the hippocampus. How the brain encodes the spatial position of others has not yet been identified. We investigated neuronal representations of other animals' locations in the dorsal CA1 region of the hippocampus with an observational T-maze task in which one rat was required to observe another rat's trajectory to successfully retrieve a reward. Information reflecting the spatial location of both the self and the other was jointly and discretely encoded by CA1 pyramidal cells in the observer rat. A subset of CA1 pyramidal cells exhibited spatial receptive fields that were identical for the self and the other. These findings demonstrate that hippocampal spatial representations include dimensions for both self and nonself.
动物对其在空间中位置的意识取决于海马体中海马位置细胞的活动。大脑如何对他人的空间位置进行编码尚不清楚。我们使用观察 T 迷宫任务研究了其他动物在海马体背侧 CA1 区的位置的神经元表示，在该任务中，一只大鼠需要观察另一只大鼠的轨迹才能成功获得奖励。反映自我和他人空间位置的信息由观察者大鼠的 CA1 锥体神经元共同且离散地编码。CA1 锥体神经元的一个子集表现出对自我和他人的空间感受野完全相同。这些发现表明，海马体的空间表示包括自我和非自我的维度。
