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感染表现为中风、脑膜脑炎,伴有主动脉和锁骨下动脉瘤,无肺部受累。

infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement.

作者信息

Sarathchandran Pournamy, Al Madani Abubaker, Alboudi Ayman M, Inshasi Jihad

机构信息

Department of Neurology, Rashid Hospital, Dubai, United Arab Emirates.

出版信息

BMJ Case Rep. 2018 Jan 11;2018:bcr-2017-221831. doi: 10.1136/bcr-2017-221831.

Abstract

A 39-year-old Philipino man presented with acute onset fever and headache. Neurological examination was normal except for neck stiffness. There was no history of chest pain, cough or breathlessness. Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis. CSF PCR for herpes simplex and varicella zoster virus was negative. He developed acute right haemiplegia a week after hospitalisation. MRI showed acute infarct in the left centrum semiovale. His angiogram showed aneurysm in the left subclavian artery and aortic arch. The mycoplasma antibody test came positive with very high titres, while rest of the workup was negative. He was treated with azithromycin and his symptoms improved completely.He was asymptomatic on follow-up after a month. His repeat immunoglobulin G mycoplasma antibody titre showed elevation. Mycoplasma infection is a treatable cause of meningoencephalitis and stroke secondary to vasculitis. Arterial aneurysms are known to occur with mycoplasma infection although rare.

摘要

一名39岁的菲律宾男子出现急性发热和头痛症状。神经系统检查除颈部僵硬外均正常。无胸痛、咳嗽或呼吸急促病史。脑脊液(CSF)显示蛋白轻度升高,糖正常,淋巴细胞增多。单纯疱疹病毒和水痘带状疱疹病毒的脑脊液聚合酶链反应(PCR)为阴性。住院一周后,他出现急性右侧偏瘫。磁共振成像(MRI)显示左侧半卵圆中心急性梗死。血管造影显示左锁骨下动脉和主动脉弓有动脉瘤。支原体抗体检测呈高滴度阳性,而其他检查均为阴性。他接受了阿奇霉素治疗,症状完全改善。一个月后随访时他无症状。他的免疫球蛋白G支原体抗体滴度复查显示升高。支原体感染是继发于血管炎的脑膜脑炎和中风的可治疗病因。虽然罕见,但已知支原体感染会并发动脉动脉瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b02c/5778324/30166afe803f/bcr-2017-221831f01.jpg

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