2型糖尿病遗传风险评分与非裔美国人中心血管代谢状况相关的2型糖尿病风险增加有关。
Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status.
作者信息
Layton Jill, Li Xiaochen, Shen Changyu, de Groot Mary, Lange Leslie, Correa Adolfo, Wessel Jennifer
机构信息
Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Department of Biostatistics, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
出版信息
Clin Med Insights Endocrinol Diabetes. 2018 Jan 3;11:1179551417748942. doi: 10.1177/1179551417748942. eCollection 2018.
The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. In cardiometabolic-stratified models, the BCD and IR GRS were associated with increased type 2 diabetes risk among 5 cardiometabolic strata: 3 clinically healthy strata and 2 clinically unhealthy strata. Genetic risk scores related to BCD and IR were associated with increased risk of type 2 diabetes in African Americans. Notably, the GRSs were significant predictors of type 2 diabetes among individuals in clinically normal ranges of cardiometabolic traits.
与葡萄糖稳态相关的遗传风险变异与2型糖尿病风险之间的关系在非裔美国人中尚未得到充分研究。我们汇总了4项前瞻性研究的数据，这些研究共纳入了4622名非裔美国人，以评估β细胞功能障碍（BCD）和/或胰岛素抵抗（IR）的遗传变异是否与2型糖尿病风险增加相关。BCD遗传风险评分（GRS）以及综合的BCD/IR GRS均与2型糖尿病风险增加显著相关。在心血管代谢分层模型中，BCD和IR GRS与5个心血管代谢分层中的2型糖尿病风险增加相关，这5个分层包括3个临床健康分层和2个临床不健康分层。与BCD和IR相关的遗传风险评分与非裔美国人患2型糖尿病的风险增加相关。值得注意的是，在心血管代谢特征处于临床正常范围的个体中，GRS是2型糖尿病的重要预测指标。
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