Hendershot Christian S, Nona Christina N
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Curr Addict Rep. 2017 Dec;4(4):364-378. doi: 10.1007/s40429-017-0173-8. Epub 2017 Sep 30.
Human laboratory studies involving alcohol administration have generated critical knowledge about individual differences in risk for alcohol use disorder (AUD), but have primarily involved adult populations and cross-sectional research designs. Ethical constraints have largely precluded human laboratory alcohol research in adolescence, and prospective studies have been rare. This paper provides an overview of developmental considerations in human laboratory alcohol research, with a focus on studies conducted with youth.
Recent human laboratory studies from Europe and Canada have examined aspects of alcohol response during late adolescence, while recent survey studies from the United States have highlighted methods for circumventing alcohol administration in studies of adolescents.
Across several decades of research, exceedingly few laboratory studies have examined developmental differences in alcohol responses or utilized prospective designs. Efforts to prioritize prospective research would further clarify the role of alcohol sensitivity traits as predictors or markers of AUD onset and progression.
涉及酒精摄入的人体实验室研究已产生了关于酒精使用障碍（AUD）风险个体差异的关键知识，但主要涉及成年人群体和横断面研究设计。伦理限制在很大程度上排除了青少年人体实验室酒精研究，前瞻性研究也很少见。本文概述了人体实验室酒精研究中的发育考量因素，重点关注针对青少年开展的研究。
欧洲和加拿大近期的人体实验室研究考察了青春期后期酒精反应的各个方面，而美国近期的调查研究则强调了在青少年研究中规避酒精摄入的方法。
在几十年的研究中，极少有实验室研究考察酒精反应的发育差异或采用前瞻性设计。将前瞻性研究作为优先事项的努力将进一步阐明酒精敏感性特征作为AUD发病和进展的预测指标或标志物的作用。
