Lee Hyo-Jun, Baek Seung-Soo
Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea.
J Exerc Rehabil. 2017 Dec 27;13(6):617-620. doi: 10.12965/jer.1735188.594. eCollection 2017 Dec.
Regular exercise reduces depressive-like behavior activation. In this study, we look for exact roles of exercise on molecular and neuronal mechanisms for antidepressant action by studying the hippocampal neuroplasticity and proliferation. Increased hippocampal neurogenesis with exercise has potential significance for depression. Exercise promotes brain health in the molecular levels in the hippocampus and also affects behavior in a similar way to chronic antidepressant treatment. Wingless (Wnt) and frizzled signaling system plays an important role in cell proliferation, growth, and differentiation during development. Our results demonstrate complicated, differential effects of antidepressants on Wnt signaling system, and assume a role for selected signaling molecules in the neurogenic activity of antidepressant care. Our review suggests that exercise may preserve brain function by increasing neurogenesis through activating Wnt signaling pathway in the psychiatric disorders, such as depression.
规律运动可减少抑郁样行为激活。在本研究中，我们通过研究海马神经可塑性和增殖来探寻运动在抗抑郁作用的分子和神经元机制中的确切作用。运动导致海马神经发生增加对抑郁症具有潜在意义。运动在分子水平上促进海马体的大脑健康，并且在影响行为方面与慢性抗抑郁治疗相似。无翅型（Wnt）和卷曲蛋白信号系统在发育过程中的细胞增殖、生长和分化中起重要作用。我们的结果表明抗抑郁药对Wnt信号系统有复杂的、差异性的影响，并假定某些信号分子在抗抑郁治疗的神经发生活性中发挥作用。我们的综述表明，运动可能通过激活精神疾病（如抑郁症）中的Wnt信号通路来增加神经发生，从而保护大脑功能。
