• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PI3K-Akt-Wnt信号通路与运动诱导的脑瘫大鼠短期记忆改善有关。

PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats.

作者信息

Cho Jung-Wan, Jung Sun-Young, Kim Dae-Young, Chung Yong-Rak, Choi Hyun-Hee, Jeon Jung-Won, Han Jin-Hee

机构信息

Department of Physical Therapy, Kyung Hee University Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea.

Department of Physical Therapy, Hosan University, Gyeongsan, Korea.

出版信息

Int Neurourol J. 2018 Oct;22(Suppl 3):S156-164. doi: 10.5213/inj.1836224.112. Epub 2018 Oct 31.

DOI:10.5213/inj.1836224.112
PMID:30396265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6234731/
Abstract

PURPOSE

Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, and GSK-3β is known to modulate hippocampal neurogenesis negatively.

METHODS

Cerebral palsy was made by maternal LPS-injection. On the 5 weeks after birth, treadmill running was applied to the rat pups of the exercise groups, for 30 minutes, 5 times a week during 6 weeks.

RESULTS

Treadmill running alleviated short-term memory impairments of the cerebral palsy rat pups. Hippocampal cell proliferation was increased and hippocampal apoptosis was suppressed by treadmill running in the cerebral palsy rat pups. Hippocampal phosphorylated-PI3K/PI3K ratio, phosphorylated-Akt/Akt ratio, and Wnt expression were enhanced by treadmill running in the cerebral palsy rat pups. In contrast, hippocampal phosphorylated-GSK-3β/GSK-3β ratio and β-catenin expression were suppressed by treadmill running in the cerebral palsy rat pups.

CONCLUSION

The results of this study showed that short-term memory improvement due to treadmill running in cerebral palsy occurs via activation of the PI3K-Akt-Wnt pathway.

摘要

目的

母体注射脂多糖（LPS）会诱发神经发育障碍，如脑瘫。运动可激活磷脂酰肌醇3激酶（PI3K）-蛋白激酶B（Akt）信号通路，增强神经发生。Wnt配体也与海马神经发生和突触可塑性有关。糖原合酶激酶-3β（GSK-3β）是Akt的下游分子，已知其对海马神经发生具有负调节作用。

方法

通过母体注射LPS制造脑瘫模型。出生后5周，对运动组的幼鼠进行跑步机跑步训练，每次30分钟，每周5次，持续6周。

结果

跑步机跑步减轻了脑瘫幼鼠的短期记忆损伤。跑步机跑步增加了脑瘫幼鼠的海马细胞增殖，抑制了海马细胞凋亡。跑步机跑步增强了脑瘫幼鼠海马中磷酸化PI3K/PI3K比值、磷酸化Akt/Akt比值和Wnt表达。相反，跑步机跑步抑制了脑瘫幼鼠海马中磷酸化GSK-3β/GSK-3β比值和β-连环蛋白表达。

结论

本研究结果表明，脑瘫幼鼠通过跑步机跑步改善短期记忆是通过激活PI3K-Akt-Wnt通路实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/8a58f9de6bca/inj-1836224-112f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/f5a78de1cc76/inj-1836224-112f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/d29564b7ec98/inj-1836224-112f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/166a554244ce/inj-1836224-112f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/4aa478a0e9a2/inj-1836224-112f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/9cf006ed8aca/inj-1836224-112f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/c838b688135b/inj-1836224-112f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/379ae9076391/inj-1836224-112f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/8a58f9de6bca/inj-1836224-112f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/f5a78de1cc76/inj-1836224-112f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/d29564b7ec98/inj-1836224-112f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/166a554244ce/inj-1836224-112f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/4aa478a0e9a2/inj-1836224-112f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/9cf006ed8aca/inj-1836224-112f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/c838b688135b/inj-1836224-112f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/379ae9076391/inj-1836224-112f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/6234731/8a58f9de6bca/inj-1836224-112f8.jpg

相似文献

1
PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats.PI3K-Akt-Wnt信号通路与运动诱导的脑瘫大鼠短期记忆改善有关。
Int Neurourol J. 2018 Oct;22(Suppl 3):S156-164. doi: 10.5213/inj.1836224.112. Epub 2018 Oct 31.
2
Treadmill exercise improves motor and memory functions in cerebral palsy rats through activation of PI3K-Akt pathway.跑步机运动通过激活PI3K-Akt信号通路改善脑瘫大鼠的运动和记忆功能。
J Exerc Rehabil. 2017 Apr 30;13(2):136-142. doi: 10.12965/jer.1734964.482. eCollection 2017 Apr.
3
Treadmill exercise activates PI3K/Akt signaling pathway leading to GSK-3β inhibition in the social isolated rat pups.跑步机运动激活PI3K/Akt信号通路，导致社会隔离的幼鼠中GSK-3β受到抑制。
J Exerc Rehabil. 2018 Feb 26;14(1):4-9. doi: 10.12965/jer.1836054.027. eCollection 2018 Feb.
4
Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats.跑步机运动通过抑制链脲佐菌素诱导的糖尿病大鼠中的糖原合酶激酶-3β表达来降低阿尔茨海默病的发病率。
J Exerc Rehabil. 2015 Apr 30;11(2):87-94. doi: 10.12965/jer.150198. eCollection 2015 Apr.
5
Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.运动通过挽救老年大鼠中下调的Wnt/β-连环蛋白信号通路来减轻脑衰老。
Front Aging Neurosci. 2020 Apr 23;12:105. doi: 10.3389/fnagi.2020.00105. eCollection 2020.
6
Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats. treadmill 运动对应激大鼠海马内 BDNF 介导电通路的影响。
Neurosci Res. 2013 Aug;76(4):187-94. doi: 10.1016/j.neures.2013.04.005. Epub 2013 May 9.
7
Treadmill exercise in obese maternal rats during pregnancy improves short-term memory through neurogenesis in the hippocampus of rat pups.孕期肥胖母鼠进行跑步机运动可通过新生大鼠海马体中的神经发生改善短期记忆。
J Exerc Rehabil. 2020 Oct 27;16(5):392-397. doi: 10.12965/jer.2040618.309. eCollection 2020 Oct.
8
Treadmill exercise ameliorates Alzheimer disease-associated memory loss through the Wnt signaling pathway in the streptozotocin-induced diabetic rats.跑步机运动通过Wnt信号通路改善链脲佐菌素诱导的糖尿病大鼠的阿尔茨海默病相关记忆丧失。
J Exerc Rehabil. 2016 Aug 31;12(4):276-83. doi: 10.12965/jer.1632678.339. eCollection 2016 Aug.
9
Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups.孕期肥胖母鼠进行跑步机运动可通过激活幼鼠海马体中的磷脂酰肌醇3激酶途径来改善空间记忆。
J Exerc Rehabil. 2020 Dec 28;16(6):483-488. doi: 10.12965/jer.2040822.411. eCollection 2020 Dec.
10
Hypoxic postconditioning activates the Wnt/β-catenin pathway and protects against transient global cerebral ischemia through Dkk1 Inhibition and GSK-3β inactivation.低氧后处理通过抑制 Dkk1 和失活 GSK-3β 激活 Wnt/β-连环蛋白通路，对短暂性全脑缺血起到保护作用。
FASEB J. 2019 Aug;33(8):9291-9307. doi: 10.1096/fj.201802633R. Epub 2019 May 23.

引用本文的文献

1
Diagnosis and therapies for patients with cerebral palsy over the past 30 years: a bibliometric analysis.过去30年脑瘫患者的诊断与治疗：一项文献计量分析
Front Neurol. 2024 Apr 17;15:1354311. doi: 10.3389/fneur.2024.1354311. eCollection 2024.
2
Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations.COVID-19 mRNA 疫苗 BNT162b2 对雄性新生大鼠的产前暴露会引起自闭症样行为：对 WNT 和 BDNF 信号转导紊乱的深入了解。
Neurochem Res. 2024 Apr;49(4):1034-1048. doi: 10.1007/s11064-023-04089-2. Epub 2024 Jan 10.
3

本文引用的文献

1
Treadmill exercise ameliorates social isolation-induced depression through neuronal generation in rat pups.跑步机运动通过新生神经元改善幼鼠社会隔离诱导的抑郁。
J Exerc Rehabil. 2017 Dec 27;13(6):627-633. doi: 10.12965/jer.1735180.590. eCollection 2017 Dec.
2
Role of exercise on molecular mechanisms in the regulation of antidepressant effects.运动在抗抑郁作用调节中的分子机制作用
J Exerc Rehabil. 2017 Dec 27;13(6):617-620. doi: 10.12965/jer.1735188.594. eCollection 2017 Dec.
3
Treadmill exercise improves motor and memory functions in cerebral palsy rats through activation of PI3K-Akt pathway.
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
有氧运动通过激活 AKT/SEC24D 促进 SREBP2 的核易位，有助于维持胆固醇稳态，改善 APP/PS1 小鼠的认知能力。
Int J Mol Sci. 2023 Aug 16;24(16):12847. doi: 10.3390/ijms241612847.
4
Genome-wide analysis of transcription factors in hippocampal tissue of cerebral palsy rats after acupuncture treatment.针刺治疗后脑瘫大鼠海马组织中转录因子的全基因组分析
Am J Transl Res. 2023 Apr 15;15(4):2622-2633. eCollection 2023.
5
Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration.解锁鸢尾素的治疗潜力：利用其在退行性疾病和组织再生中的功能。
Int J Mol Sci. 2023 Mar 31;24(7):6551. doi: 10.3390/ijms24076551.
6
Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway.腺嘌呤 A2A 受体激动剂聚脱氧核糖核苷酸通过 MAPK 通路抑制脑缺血诱导的炎症改善短期记忆障碍。
PLoS One. 2021 Mar 18;16(3):e0248689. doi: 10.1371/journal.pone.0248689. eCollection 2021.
7
Protective Effect of Polydeoxyribonucleotide Against CCl4-Induced Acute Liver Injury in Mice.聚脱氧核糖核苷酸对四氯化碳诱导的小鼠急性肝损伤的保护作用
Int Neurourol J. 2020 Nov;24(Suppl 2):88-95. doi: 10.5213/inj.2040430.215. Epub 2020 Nov 23.
8
Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats.小檗碱改善泊洛沙姆407诱导的高脂血症大鼠的脑炎症。
Int Neurourol J. 2019 Nov;23(Suppl 2):S102-110. doi: 10.5213/inj.1938216.108. Epub 2019 Nov 30.
9
The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring.连接蛋白43半通道的开放改变了产前暴露于脂多糖的成年子代海马星形胶质细胞功能和神经元存活。
Front Cell Neurosci. 2019 Oct 11;13:460. doi: 10.3389/fncel.2019.00460. eCollection 2019.
10
Treadmill exercise ameliorates nicotine withdrawal-induced symptoms.跑步机运动可改善尼古丁戒断引起的症状。
J Exerc Rehabil. 2019 Jun 30;15(3):383-391. doi: 10.12965/jer.1938228.114. eCollection 2019 Jun.
跑步机运动通过激活PI3K-Akt信号通路改善脑瘫大鼠的运动和记忆功能。
J Exerc Rehabil. 2017 Apr 30;13(2):136-142. doi: 10.12965/jer.1734964.482. eCollection 2017 Apr.
4
Treadmill exercise ameliorates symptoms of Alzheimer disease through suppressing microglial activation-induced apoptosis in rats.跑步机运动通过抑制大鼠小胶质细胞激活诱导的细胞凋亡来改善阿尔茨海默病症状。
J Exerc Rehabil. 2016 Dec 31;12(6):526-534. doi: 10.12965/jer.1632858.429. eCollection 2016 Dec.
5
Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?靶向胃癌中的磷脂酰肌醇-3-激酶通路：组学能否改善治疗结果？
Int Neurourol J. 2016 Nov;20(Suppl 2):S131-140. doi: 10.5213/inj.1632740.370. Epub 2016 Nov 22.
6
Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway.依托咪酯通过磷酸肌醇 3-激酶（PI3K）/Akt/Wnt/β-连环蛋白通路诱导海马神经发生并逆转淀粉样β毒素诱导的阿尔茨海默病大鼠模型中的认知缺陷。
J Biol Chem. 2015 Nov 20;290(47):28540-28558. doi: 10.1074/jbc.M115.652586. Epub 2015 Sep 29.
7
The role of GSK3beta in the development of the central nervous system.糖原合成酶激酶3β在中枢神经系统发育中的作用。
Front Biol (Beijing). 2012 Jun;7(3):212-220. doi: 10.1007/s11515-012-1222-2.
8
Wnt pathway regulation by long-term moderate exercise in rat hippocampus.长期适度运动对大鼠海马区 Wnt 通路的调节。
Brain Res. 2014 Jan 16;1543:38-48. doi: 10.1016/j.brainres.2013.10.048. Epub 2013 Oct 29.
9
Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats. treadmill 运动对应激大鼠海马内 BDNF 介导电通路的影响。
Neurosci Res. 2013 Aug;76(4):187-94. doi: 10.1016/j.neures.2013.04.005. Epub 2013 May 9.
10
Physical exercise improves functional recovery through mitigation of autophagy, attenuation of apoptosis and enhancement of neurogenesis after MCAO in rats.体育锻炼通过减轻自噬、抑制细胞凋亡和增强脑缺血大鼠的神经发生，改善功能恢复。
BMC Neurosci. 2013 Apr 8;14:46. doi: 10.1186/1471-2202-14-46.