Yu Wan-Lei, Chen Jian-Qiang, Wei Yun-Long, Wang Zhu-Yin, Xu Peng-Fei
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Chem Commun (Camb). 2018 Feb 20;54(16):1948-1951. doi: 10.1039/c7cc09151f.
A novel strategy involving visible-light-induced functionalization of alkenes for the synthesis of substituted aziridines was developed. The readily prepared N-protected 1-aminopyridinium salts were used for the generation of N-centered radicals. This approach allowed the synthesis of aziridines bearing various functional groups with excellent diastereoselectivity under mild conditions. Moreover, this protocol was successfully applied to prepare structurally diverse nitrogen-containing frameworks.
开发了一种涉及可见光诱导烯烃官能化以合成取代氮丙啶的新策略。易于制备的N-保护的1-氨基吡啶盐用于生成以N为中心的自由基。该方法能够在温和条件下以优异的非对映选择性合成带有各种官能团的氮丙啶。此外，该方案已成功应用于制备结构多样的含氮骨架。
