Yamane Tomohiko, Kuji Ichiei, Seto Akira, Matsunari Ichiro
Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, 350-1298, Japan.
Division of Nuclear Medicine, Department of Radiology, Saitama Medical University Hospital, Moroyama, Japan.
Skeletal Radiol. 2018 Jun;47(6):805-810. doi: 10.1007/s00256-017-2861-9. Epub 2018 Jan 11.
Quantifying the function of the epiphyseal plate is worthwhile for the management of children with growth disorders. The aim of this retrospective study was to quantify the osteoblastic activity at the epiphyseal plate using the quantitative bone SPECT/CT.
We enrolled patients under the age of 20 years who received Tc-99m hydroxymethylene diphosphonate bone scintigraphy acquired by a quantitative SPECT/CT scanner. The images were reconstructed by ordered subset conjugate-gradient minimizer, and the uptake on the distal margin of the femur was quantified by peak standardized uptake value (SUVpeak). A public database of standard body height was used to calculate growth velocities (cm/year).
Fifteen patients (6.9-19.7 years, 9 female, 6 male) were enrolled and a total of 25 legs were analyzed. SUVpeak in the epiphyseal plate was 18.9 ± 2.4 (average ± standard deviation) in the subjects under 15 years and decreased gradually by aging. The SUVpeak correlated significantly with the age- and sex-matched growth velocity obtained from the database (R = 0.83, p < 0.0001).
The SUV measured by quantitative bone SPECT/CT was increased at the epiphyseal plates of children under the age of 15 years in comparison with the older group, corresponding to higher osteoblastic activity. Moreover, this study suggested a correlation between growth velocity and the SUV. Although this is a small retrospective pilot study, the objective and quantitative values measured by the quantitative bone SPECT/CT has the potential to improve the management of children with growth disorder.
量化骨骺板的功能对于生长障碍儿童的管理具有重要意义。本回顾性研究的目的是使用定量骨SPECT/CT来量化骨骺板处的成骨细胞活性。
我们纳入了20岁以下接受定量SPECT/CT扫描仪进行的锝-99m亚甲基二膦酸盐骨闪烁显像的患者。图像采用有序子集共轭梯度最小化算法重建，股骨远端边缘的摄取通过峰值标准化摄取值（SUVpeak）进行量化。使用标准身高公共数据库计算生长速度（厘米/年）。
共纳入15例患者（年龄6.9 - 19.7岁，女性9例，男性6例），共分析了25条腿。15岁以下受试者骨骺板处的SUVpeak为18.9±2.4（平均值±标准差），并随年龄增长逐渐降低。SUVpeak与从数据库中获得的年龄和性别匹配的生长速度显著相关（R = 0.83，p < 0.0001）。
与年龄较大的组相比，定量骨SPECT/CT测量的SUV在15岁以下儿童的骨骺板处升高，这与较高的成骨细胞活性相对应。此外，本研究表明生长速度与SUV之间存在相关性。虽然这是一项小型回顾性试点研究，但定量骨SPECT/CT测量的客观和定量值有可能改善生长障碍儿童的管理。
