Neuroscience Institute, Lithuanian University of Health Sciences, Eiveniu g. 2, 50009, Kaunas, Lithuania.
J Neurooncol. 2018 May;137(3):593-600. doi: 10.1007/s11060-018-2751-6. Epub 2018 Jan 11.
Personality traits can be related to prognosis of cancer patients. The study aimed to evaluate the association of big-five personality dimensions with emotional and cognitive health status, and prognosis of brain tumor patients. A total of 178 patients admitted for brain tumor surgery were evaluated for personality traits (Tem item Personality Inventory), depressive/anxiety symptoms (Hospital Anxiety and Depression Scale or HADS) and cognitive functioning (Mini Mental State Examination or MMSE) on admission. One-hundred and forty-three patients were re-evaluated (HADS and MMSE scales) at hospital discharge. Follow-up continued until November, 2015. Thirty-five patients were diagnosed with high-grade glioma, 15 with low-grade glioma and 128 with benign brain tumors (meningioma, pituitary adenoma and vestibular schwannoma). In multivariate regression analyses adjusted for age, gender, past brain tumor treatment, psychiatric histories and medication use, and education, greater TIPI-Extroversion score was associated with greater admission MMSE score (β = 0.159); TIPI-Emotional stability score, with lower HADS-Depression and HADS-Anxiety scores on admission (β = - 0.407 and β = - 0.404, respectively) and at discharge (β = - 0.404 and β = - 0.319, respectively); and greater TIPI-Openness score, with lower admission HADS-D score (β = - 0.255, p = 0.001). In benign brain tumor patients, greater TIPI-Openness score was associated with reduced mortality risk [HR = 0.554 95% CI (0.376-0.814) p = 0.003)] independently from age, gender and histological diagnosis. Personality traits were not associated with survival of high-grade and low-grade glioma patients. Emotional stability and openness are associated with lower depressive/anxiety symptom severity, and extroversion with better cognitive functioning independently from demographic and clinical risk factors. Openness predicts lower mortality risk of low-grade/benign brain tumor patients.
人格特质与癌症患者的预后有关。本研究旨在评估大五人格维度与脑肿瘤患者的情绪和认知健康状况及预后的关系。共对 178 例因脑肿瘤手术入院的患者进行了人格特质评估（Tem 项目人格问卷）、抑郁/焦虑症状（医院焦虑和抑郁量表或 HADS）和认知功能（简易精神状态检查或 MMSE）。143 例患者在出院时（HADS 和 MMSE 量表）进行了重新评估。随访持续至 2015 年 11 月。35 例患者被诊断为高级别胶质瘤，15 例为低级别胶质瘤，128 例为良性脑肿瘤（脑膜瘤、垂体腺瘤和前庭神经鞘瘤）。在调整年龄、性别、既往脑肿瘤治疗、精神病史和用药情况以及教育程度的多变量回归分析中，TIPI-外向性评分越高，入院 MMSE 评分越高（β=0.159）；TIPI-情绪稳定性评分越低，入院时 HADS 抑郁和 HADS 焦虑评分越低（β=-0.407 和β=-0.404），出院时 HADS 抑郁和 HADS 焦虑评分越低（β=-0.404 和β=-0.319）；TIPI-开放性评分越高，入院时 HADS-D 评分越低（β=-0.255，p=0.001）。在良性脑肿瘤患者中，TIPI-开放性评分越高，死亡风险降低[HR=0.554 95%CI（0.376-0.814），p=0.003)]，独立于年龄、性别和组织学诊断。人格特质与高级别和低级别胶质瘤患者的生存率无关。情绪稳定性和开放性与较低的抑郁/焦虑症状严重程度相关，外向性与认知功能更好相关，独立于人口统计学和临床危险因素。开放性预测低级别/良性脑肿瘤患者的死亡率降低。
