人格与癌症发病率和死亡率有关吗？42843 名男性和女性中 2156 例癌症发病的个体参与者荟萃分析。
Is personality associated with cancer incidence and mortality? An individual-participant meta-analysis of 2156 incident cancer cases among 42,843 men and women.
机构信息
1] Institute of Behavioural Sciences, University of Helsinki, Siltavuorenpenger 1A, PO Box 9, 00014 Helsinki, Finland [2] Department of Psychology, University of Cambridge, Cambridge, UK.
1] Department of Epidemiology and Public Health, University College London, London, UK [2] Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland [3] Department of Psychology, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, Scotland.
出版信息
Br J Cancer. 2014 Apr 2;110(7):1820-4. doi: 10.1038/bjc.2014.58. Epub 2014 Feb 6.
BACKGROUND
The putative role of personality in cancer risk has been controversial, and the evidence remains inconclusive.
METHODS
We pooled data from six prospective cohort studies (British Household Panel Survey; Health and Retirement Study; Household, Income, and Labour Dynamics in Australia; Midlife in the United Survey; Wisconsin Longitudinal Study Graduate; and Sibling samples) for an individual-participant meta-analysis to examine whether personality traits of the Five Factor Model (extraversion, neuroticism, agreeableness, conscientiousness, and openness to experience) were associated with the incidence of cancer and cancer mortality in 42,843 cancer-free men and women at baseline (mean age 52.2 years, 55.6% women).
RESULTS
During an average follow-up of 5.4 years, there were 2156 incident cancer cases. In random-effects meta-analysis adjusted for age, sex, and race/ethnicity, none of the personality traits were associated with the incidence of all cancers or any of the six site-specific cancers included in the analysis (lung, colon, breast, prostate, skin, and leukaemia/lymphoma). In the three cohorts with cause-specific mortality data (421 cancer deaths among 21,835 participants), none of the personality traits were associated with cancer mortality.
CONCLUSIONS
These data suggest that personality is not associated with increased risk of incident cancer or cancer-related mortality.
背景
人格在癌症风险中的作用一直存在争议，证据仍不确定。
方法
我们对六项前瞻性队列研究（英国家庭面板调查；健康与退休研究；澳大利亚家庭、收入和劳动力动态调查；美国中年调查；威斯康星纵向研究研究生；以及兄弟姐妹样本）的数据进行了汇总，进行个体参与者荟萃分析，以检验五因素模型（外向性、神经质、宜人性、尽责性和开放性）的人格特质是否与癌症发病率和癌症死亡率相关。在基线时（平均年龄为 52.2 岁，55.6%为女性），有 42843 名无癌症的男性和女性。
结果
在平均随访 5.4 年期间，发生了 2156 例癌症新发病例。在随机效应荟萃分析中，调整了年龄、性别和种族/民族因素后，没有任何人格特质与所有癌症或分析中包括的六种特定部位癌症（肺癌、结肠癌、乳腺癌、前列腺癌、皮肤癌和白血病/淋巴瘤）的发病率相关。在具有特定原因死亡率数据的三个队列中（在 21835 名参与者中发生了 421 例癌症死亡），没有任何人格特质与癌症死亡率相关。
结论
这些数据表明，人格与癌症发病率或癌症相关死亡率的增加无关。
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