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人类免疫缺陷病毒感染患者的播散性皮肤镰刀菌病及口服伊曲康唑的显著疗效

Disseminated cutaneous fusariosis in human immunodeficiency virus-infected patient and dramatic response with oral itraconazole.

作者信息

Kumari Indu, Singh Satyendra Kumar, Chauhan Rishabh Kumar, Kaushal Satyendra Kumar

机构信息

Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

出版信息

Indian J Dermatol Venereol Leprol. 2018 May-Jun;84(3):362-368. doi: 10.4103/ijdvl.IJDVL_360_16.

Abstract

Fusarium species are known to cause disseminated cutaneous lesions in immunocompromised patients. Some cases of fusariosis are reported in patients infected with the human immunodeficiency virus. There are two reports in such patients with systemic comorbidities like lymphoma, neutropenia and infective port-a-catheter. Another reported patient had systemic fusariosis, without skin involvement. Diagnosis and treatment of cutaneous fusariosis is difficult and resistance to antifungals is a problem. Our patient was at an advanced human immunodeficiency virus infection stage with disseminated cutaneous fusariosis, without any systemic involvement, who responded completely to oral itraconazole.

摘要

已知镰刀菌属会在免疫功能低下的患者中引起播散性皮肤病变。在感染人类免疫缺陷病毒的患者中报告了一些镰刀菌病病例。在患有淋巴瘤、中性粒细胞减少症和感染性植入式静脉输液港等全身性合并症的此类患者中有两份报告。另一名报告的患者患有全身性镰刀菌病,无皮肤受累。皮肤镰刀菌病的诊断和治疗很困难,并且对抗真菌药物的耐药性是一个问题。我们的患者处于人类免疫缺陷病毒感染晚期,患有播散性皮肤镰刀菌病,无任何全身受累,对口服伊曲康唑完全有反应。

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