Department of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Org Lett. 2018 Feb 2;20(3):684-687. doi: 10.1021/acs.orglett.7b03818. Epub 2018 Jan 12.
The use of allyl-palladium catalysis for the one-step α,β-dehydrogenation of ketones via their zinc enolates is reported. The optimized protocol utilizes commercially available Zn(TMP) as base and diethyl allyl phosphate as oxidant. Notably, this transformation operates under salt-free conditions and tolerates a diverse scope of cycloalkanones.
本文报道了通过锌烯醇盐实现酮的一步α,β-脱氢反应的烯丙基钯催化反应。优化后的反应条件使用了商业可得的 Zn(TMP)作为碱，二乙基烯丙基磷酸酯作为氧化剂。值得注意的是，该转化在无盐条件下进行，并能容忍广泛范围的环烷酮。
