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吡唑衍生物作为一种抗癌剂在不同细胞系中的最新发展概述。

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.

机构信息

Laboratory of Pharmacology and Toxicology, Bio Pharmaceutical and Toxicological Analysis Research Team, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203, Rabat, Morocco; Laboratory of Therapeutic Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203, Rabat, Morocco.

Department of Biomedical Engineering Medical Physiology, Higher School of Technical Education of Rabat, Mohammed V University in Rabat, BP 6203 Rabat, Morocco.

出版信息

Bioorg Chem. 2020 Apr;97:103470. doi: 10.1016/j.bioorg.2019.103470. Epub 2019 Dec 14.

DOI:10.1016/j.bioorg.2019.103470
PMID:32120072
Abstract

Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms CHNH.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer.

摘要

吡唑是一个五元含两个相邻氮原子的芳香杂环 CHNH。在各种治疗类别的药理试剂中，该核素赋予了具有广泛生物活性的药物，如塞来昔布（抗炎）、CDPPB（抗精神病）、利莫那班（抗肥胖）、地芬那酯（镇痛药）、贝他唑（H2 受体激动剂）、非佐米（抗抑郁药）等。吡唑部分的药理潜力已在许多出版物中得到证实，这些出版物合成并评估了吡唑类化合物对几种生物制剂的作用。本文综述的目的是调查最近将吡唑结构与针对 9 种不同类型癌症的抗癌活性联系起来的工作。

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