Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Turkey.
Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Turkey.
J Neuroimmunol. 2018 Mar 15;316:121-129. doi: 10.1016/j.jneuroim.2018.01.002. Epub 2018 Jan 3.
Suppressors of cytokine signaling (SOCS) and brain-derived neurotrophic factor (BDNF) are important immunologic, and neurotrophic factors for MS pathogenesis. The impact of exercise on these factors is yet to be fully elucidated in patients with MS.
The primary aim of this study is to investigate the effect of 8-week combined exercise training on serum concentrations of SOCS1, SOCS3, and BDNF. The secondary aim is to determine the effects of combined exercise training on balance, functional exercise capacity, and fatigue in patients with MS.
Serum SOCS1, SOCS3, and BDNF levels were assessed in 36 MS patients and 18 healthy individuals. In addition, balance, functional exercise capacity, and fatigue were assessed in the patients with MS. The patients were randomly divided into the combined exercise group (MS-EX, n:18) and the control group (MS-C, n:18). MS-EX received an 8-week combined exercise training.
The serum SOCS1, SOCS3, and BDNF levels were similar in the MS patients and healthy control (HC). In MS-EX, the serum BDNF level, balance, functional exercise capacity, and fatigue improved after 8weeks (p<0.05), but the serum SOCS1, and SOCS3 levels did not change significantly (p>0.05). In MS-C, the serum SOCS1 level, and fatigue increased significantly after 8weeks (p<0.05), but serum SOCS3, BDNF, balance and functional exercise capacity did not change (p>0.05).
In summary, the combined exercise training improved BDNF, and physical performance in patients with MS. But, future studies are needed to clarify the role of SOCS proteins in MS pathogenesis and the effect of exercise on SOCS.
细胞因子信号转导抑制因子（SOCS）和脑源性神经营养因子（BDNF）是多发性硬化症（MS）发病机制中的重要免疫和神经营养因子。运动对这些因子的影响在 MS 患者中尚未得到充分阐明。
本研究的主要目的是研究 8 周联合运动训练对血清 SOCS1、SOCS3 和 BDNF 浓度的影响。次要目的是确定联合运动训练对 MS 患者平衡、功能性运动能力和疲劳的影响。
评估了 36 名 MS 患者和 18 名健康个体的血清 SOCS1、SOCS3 和 BDNF 水平。此外，还评估了 MS 患者的平衡、功能性运动能力和疲劳。患者被随机分为联合运动组（MS-EX，n=18）和对照组（MS-C，n=18）。MS-EX 接受了 8 周的联合运动训练。
MS 患者和健康对照组（HC）的血清 SOCS1、SOCS3 和 BDNF 水平相似。在 MS-EX 中，血清 BDNF 水平、平衡、功能性运动能力和疲劳在 8 周后改善（p<0.05），但血清 SOCS1 和 SOCS3 水平没有显著变化（p>0.05）。在 MS-C 中，血清 SOCS1 水平和疲劳在 8 周后显著增加（p<0.05），但血清 SOCS3、BDNF、平衡和功能性运动能力没有变化（p>0.05）。
总之，联合运动训练改善了 MS 患者的 BDNF 和身体表现。但是，需要进一步的研究来阐明 SOCS 蛋白在 MS 发病机制中的作用以及运动对 SOCS 的影响。
