染色体外环状 DNA：在癌症进展中的新潜在作用。
Extrachromosomal circular DNA: a new potential role in cancer progression.
机构信息
Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, and Research Institution of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong, 226001, Jiangsu, China.
Department of Thoracic Surgery, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong, 226001, Jiangsu, China.
出版信息
J Transl Med. 2021 Jun 10;19(1):257. doi: 10.1186/s12967-021-02927-x.
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has rich and important biological functions, and is involved in the occurrence of many diseases, including cancer. In this review, we focus on the discovery history, formation process, characteristics, and physiological functions of eccDNAs; the potential functions of various eccDNAs in human cancer; and the research methods employed to study eccDNA.
染色体外环状 DNA（eccDNA）被认为是一种广泛存在于自然界中的环状 DNA 分子，它独立于传统染色体。根据其大小和序列，eccDNA 可分为小的分散环状 DNA（spcDNA）、端粒环（t- 环）、微 DNA 和染色体外 DNA（ecDNA）。多项研究表明，eccDNA 是基因组不稳定性的产物，具有丰富而重要的生物学功能，并参与了许多疾病的发生，包括癌症。在这篇综述中，我们重点介绍了 eccDNA 的发现历史、形成过程、特征和生理功能；各种 eccDNA 在人类癌症中的潜在功能；以及研究 eccDNA 的研究方法。
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