大环内酯类敏感脓肿分枝杆菌肺病的治疗结果
Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease.
作者信息
Choi Hayoung, Jhun Byung Woo, Kim Su-Young, Kim Dae Hun, Lee Hyun, Jeon Kyeongman, Kwon O Jung, Huh Hee Jae, Ki Chang-Seok, Lee Nam Yong, Shin Sung Jae, Daley Charles L, Koh Won-Jung
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
出版信息
Diagn Microbiol Infect Dis. 2018 Apr;90(4):293-295. doi: 10.1016/j.diagmicrobio.2017.12.008. Epub 2017 Dec 16.
Mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. However, 15%-20% of isolates are macrolide susceptible. In 14 patients with macrolide-susceptible M. abscessus lung disease, all isolates had nonfunctional erm(41) gene, and sputum culture conversion rate was achieved in 93% (13/14) following antibiotic therapy.
脓肿分枝杆菌肺病因对大环内酯类药物具有诱导性耐药而难以治疗。然而，15% - 20%的分离株对大环内酯类药物敏感。在14例对大环内酯类药物敏感的脓肿分枝杆菌肺病患者中，所有分离株的erm(41)基因均无功能，抗生素治疗后痰培养转阴率达93%（13/14）。
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