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Hypersensitivity to DNA-damaging agents in abiotrophies: a new explanation for degeneration of neurons, photoreceptors, and muscle in Alzheimer, Parkinson and Huntington diseases, retinitis pigmentosa, and Duchenne muscular dystrophy.

作者信息

Robbins J H, Brumback R A, Polinsky R J, Wirtschafter J D, Tarone R E, Scudiero D A, Otsuka F

出版信息

Basic Life Sci. 1985;35:315-44. doi: 10.1007/978-1-4899-2218-2_20.

DOI:10.1007/978-1-4899-2218-2_20
PMID:2933027
Abstract
摘要

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1
Hypersensitivity to DNA-damaging agents in abiotrophies: a new explanation for degeneration of neurons, photoreceptors, and muscle in Alzheimer, Parkinson and Huntington diseases, retinitis pigmentosa, and Duchenne muscular dystrophy.营养缺陷型中对DNA损伤剂的超敏反应:对阿尔茨海默病、帕金森病、亨廷顿病、色素性视网膜炎和杜兴氏肌营养不良症中神经元、光感受器和肌肉退化的新解释。
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2
Hypersensitivity to DNA-damaging agents in cultured cells from patients with Usher's syndrome and Duchenne muscular dystrophy.患有尤塞氏综合征和杜兴氏肌肉营养不良症患者的培养细胞对DNA损伤剂的超敏反应。
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Tau 丝氨酸 262 位磷酸化对于阿尔茨海默病转基因果蝇模型中 Abeta42 诱导的 tau 毒性至关重要。
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