Nove J, Tarone R E, Little J B, Robbins J H
Mutat Res. 1987 Jul;184(1):29-38. doi: 10.1016/0167-8817(87)90033-2.
The colony-forming ability of 10 normal human fibroblast cell strains and of 10 strains representing 3 degenerative diseases of either nerve or muscle cells was determined after exposure of the cells to X-rays or beta-particles from tritiated water. Both methods of irradiation yielded similar comparative results. The fibroblast strains from the 5 Usher's syndrome patients and from 1 of the 2 Huntington's disease patients were hypersensitive to radiation, while those from the 3 Duchenne muscular dystrophy patients and the second Huntington's disease patient had normal sensitivity to radiation. These results indicate both disease-specific and strain-specific differences in the survival of fibroblasts after exposure to ionizing radiation.
在将10种正常人类成纤维细胞系以及代表神经或肌肉细胞3种退行性疾病的10种细胞系暴露于X射线或氚化水产生的β粒子后，测定了它们的集落形成能力。两种辐照方法产生了相似的比较结果。来自5名Usher综合征患者和2名亨廷顿舞蹈病患者中1人的成纤维细胞系对辐射高度敏感，而来自3名杜氏肌营养不良患者和另1名亨廷顿舞蹈病患者的成纤维细胞系对辐射具有正常敏感性。这些结果表明，暴露于电离辐射后，成纤维细胞的存活存在疾病特异性和细胞系特异性差异。
