Guaschino S, Spinillo A, Sances G, Martignoni E
Clin Exp Obstet Gynecol. 1985;12(3-4):67-71.
The authors reviewed the connection between sexual hormones and migraine crisis. Besides other exogenous factors, the fall of estradiol blood levels in the late luteal and premenstrual phase seems a causal factor in the origin of menstrual-related headache crisis. The behaviour of migraine crisis during the various events of female reproductive life, support this view. The role of PRL, T, FSH and LH was also discussed. On the other hand, menstrual migraine represents a model that fits perfectly with a neuroendocrine hypothesis which is based upon a faulty chronobiological response of the so-called antinociceptive system.
作者回顾了性激素与偏头痛发作之间的联系。除其他外源性因素外，黄体后期和经前期雌二醇血水平下降似乎是与月经相关的头痛发作的一个致病因素。女性生殖生活各阶段偏头痛发作的表现支持了这一观点。文中还讨论了催乳素、睾酮、促卵泡激素和促黄体生成素的作用。另一方面，月经性偏头痛是一个与神经内分泌假说完美契合的模型，该假说基于所谓的抗伤害感受系统的生物钟反应错误。
