重组γ干扰素是小鼠疟疾疫苗的一种有效佐剂。
Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.
作者信息
Playfair J H, De Souza J B
出版信息
Clin Exp Immunol. 1987 Jan;67(1):5-10.
Abstract
Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneally or subcutaneously. Specific immune responses that were enhanced included antibody, T cell help, and delayed hypersensitivity.
摘要
用经Triton X - 100裂解的全寄生红细胞对小鼠进行接种，可使其免受致死性约氏疟原虫疟疾的侵害。为达到完全有效性，这种疫苗需要一种佐剂，并且我们发现，重组γ干扰素在该模型中经腹腔内或皮下注射时具有很强的佐剂活性。增强的特异性免疫反应包括抗体、T细胞辅助和迟发型超敏反应。
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