The Clinic of Family Medicine, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey.
Nagoya J Med Sci. 2022 Feb;84(1):101-110. doi: 10.18999/nagjms.84.1.101.
It was aimed to evaluate the relationship between frailty and inflammation in people receiving home health care. It was a cross-sectional study. Edmonton Frail Scale was used to determine the level of frailty and, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were used to determine inflammation. Of 332 people included in the study, 54.82% were females and 45.18% were males. Participants' ages were between 65 and 106. When we examined the frailty of the participants according to the Edmonton Frail Scale, the mean score was 9.403 ± 2.032. The mean neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio of the participants were 4,397±5,038 and 169,363±101,461 respectively. Accordingly, neutrophil-to-lymphocyte ratio was high in men, frail elderly, 75-84 age range, hypertension patients, malnutrition patients; and neutrophil-to-lymphocyte ratio was low in diabetes mellitus, dementia, cerebrovascular accident and hemiplegia. Platelet-to-lymphocyte ratio, another inflammatory marker, was high in men, non-frail elderly, 75-84 age range, hypertension patients and cerebrovascular accident patients; it was low in hemiplegia, malnutrition, dementia, diabetes mellitus. In the study, no statistically significant difference was found between Edmonton Frail Scale and inflammatory markers. More studies are needed on this subject. In addition, we think that examining NLR and PLR values will be useful for monitoring inflammation in frail elderly.
评估接受家庭保健的人群中衰弱与炎症之间的关系。这是一项横断面研究。使用埃德蒙顿衰弱量表来确定衰弱程度,中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值来确定炎症程度。在纳入的 332 名研究对象中,54.82%为女性,45.18%为男性。参与者年龄在 65 至 106 岁之间。当我们根据埃德蒙顿衰弱量表评估参与者的衰弱程度时,平均得分为 9.403 ± 2.032。参与者的中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值的平均值分别为 4397±5038 和 169363±101461。相应地,中性粒细胞与淋巴细胞比值在男性、虚弱的老年人、75-84 岁年龄组、高血压患者、营养不良患者中较高;在糖尿病、痴呆、脑血管意外和偏瘫患者中较低。血小板与淋巴细胞比值是另一种炎症标志物,在男性、非虚弱的老年人、75-84 岁年龄组、高血压患者和脑血管意外患者中较高;在偏瘫、营养不良、痴呆、糖尿病患者中较低。在该研究中,埃德蒙顿衰弱量表与炎症标志物之间未发现统计学显著差异。需要对此主题进行更多研究。此外,我们认为检查 NLR 和 PLR 值将有助于监测虚弱老年人的炎症。